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MetabolomicsImmunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
The major function of B lymphocytes is to sense antigens and to produce protective antibodies after activation. This function requires the expression of a B-cell antigen receptor (BCR), and evolutionary conserved mechanisms seem to exist that ensure that B cells without a BCR do not develop nor surv...
2020-04-21 | MTBLS186 | MetaboLights
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle

To elucidate the function of oxidative phosphorylation (OxPhos) during B-cell differentiation we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abun...

2026-08-21 | MTBLS4647 | MetaboLights
TranscriptomicsInfection of naïve primary human B-lymphocytes with Epstein-Barr virus (EBV) – time course transcriptomic analysis in the pre-latent phase of viral infection
B cells from anonymous adenoid donors were isolated and sorted for naïve B cells, which were subsequently infected with a reference EBV strain (2089_B95-8) using a defined multiplicity of infection. Infection of resting B cells with EBV induces their activation, their proliferation, and subsequent i...
ORGANISM(S): Homo sapiens 
2019-07-01 | E-MTAB-7805 | biostudies-arrayexpress
TranscriptomicsMiR-21 function in T-lymphocytes
T-lymphocyte activation is efficiently mimicked in vitro by treatment with anti CD3 / anti CD28 antibodies. We report miR-21 induction upon CD3/CD28 stimulation of primary T-lymphocytes. In order to assess the function of miR-21 in T-lymphocytes we interfered with miR-21 function by lentiviral trans...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-37213 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T-lymphocytes from the adaptive immune system from smojers and non smokers
Cigarette smoke components have a proven negative influence on human health. Adverse metabolic effects have been observed in tissues and single cells. As T-lymphocytes get in contact with affected organs (e.g. lung) or cells (e.g.erythrocytes), as well as with smoke components and bioactive molecule...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4806 | biostudies-arrayexpress
OtherProteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry.
Data from PASSEL: [[https://db.systemsbiology.net/sbeams/cgi/PeptideAtlas/PASS_View?datasetPassword=QU5589mw&identifier=PASS00016 PASS00016]]. Experiment: 0hr-chrom, file: 0hr-chrom_1d.mzXML. Data published as part of Mol Syst Biol. 2012 8:573 . From the Abstract: {{i}}Regulating the transition of ...
ORGANISM(S): Human, Human_adenovirus_54, Human_adenovirus_a, Human_adenovirus_b, Human_adenovirus_c, Human_adenovirus_d, Human_adenovirus_e, Human_adenovirus_f, Human_adenovirus_g, Human_astrovirus, Human_bocavirus, Human_bocavirus_2, Human_bocavirus_3, Human_bocavirus_4, Human_coronavirus_229e, Human_coronavirus_hku1, Human_coronavirus_nl63, Human_coronavirus_oc43, Human_cosavirus_a, Human_cosavirus_b, Human_cosavirus_d, Human_cosavirus_e, Human_enteric_coronavirus_4408, Human_enterovirus_100, Human_enterovirus_a, Human_enterovirus_b, Human_enterovirus_c, Human_enterovirus_d, Human_erythrovirus_v9, Human_herpesvirus_1, Human_herpesvirus_2, Human_herpesvirus_3, Human_herpesvirus_4_type_1, Human_herpesvirus_4_type_2, Human_herpesvirus_5, Human_herpesvirus_6a, Human_herpesvirus_6b, Human_herpesvirus_7, Human_herpesvirus_8_type_p, Human_immunodeficiency_virus_1, Human_immunodeficiency_virus_2, Human_metapneumovirus, Human_papillomavirus_fa75_ki88_03, Human_papillomavirus_rtrx7, Human_papillomavirus_type_10, Human_papillomavirus_type_100, Human_papillomavirus_type_101, Human_papillomavirus_type_103, Human_papillomavirus_type_104, Human_papillomavirus_type_105, Human_papillomavirus_type_108, Human_papillomavirus_type_109, Human_papillomavirus_type_112, Human_papillomavirus_type_113, Human_papillomavirus_type_16, Human_papillomavirus_type_24, Human_papillomavirus_type_26, Human_papillomavirus_type_32, Human_papillomavirus_type_34, Human_papillomavirus_type_4, Human_papillomavirus_type_41, Human_papillomavirus_type_48, Human_papillomavirus_type_49, Human_papillomavirus_type_5, Human_papillomavirus_type_50, Human_papillomavirus_type_53, Human_papillomavirus_type_60, Human_papillomavirus_type_63, Human_papillomavirus_type_6b, Human_papillomavirus_type_7, Human_papillomavirus_type_71, Human_papillomavirus_type_88, Human_papillomavirus_type_9, Human_papillomavirus_type_92, Human_papillomavirus_type_96, Human_papillomavirus_type_98, Human_papillomavirus_type_99, Human_papillomavirus___1, Human_papillomavirus___18, Human_papillomavirus___2, Human_papillomavirus___54, Human_papillomavirus___61, Human_papillomavirus___cand90, Human_parainfluenza_virus_1, Human_parainfluenza_virus_2, Human_parainfluenza_virus_3, Human_parechovirus, Human_parvovirus_4, Human_parvovirus_b19, Human_picobirnavirus, Human_respiratory_syncytial_virus, Human_rhinovirus_a, Human_rhinovirus_b, Human_rhinovirus_c, Human_tmev_like_cardiovirus, Human_t_lymphotropic_virus_1, Human_t_lymphotropic_virus_2, Human_t_lymphotropic_virus_4 
GPM11210014830 | GPMDB
GenomicsSequence and expression analysis of human chromosome 20 gaps
The finished human genome-assemblies comprise several hundred un-sequenced euchromatic gaps, which may be rich in long polypurine/polypyrimidine stretches. Human chromosome 20 currently has three remaining un-sequenced gaps on its q-arm. All three gaps are within gene-dense regions, or overlap loci ...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-35405 | biostudies-arrayexpress
ProteomicsProteomic changes of CD19+ B Lymphocytes in COVID-19 Patients
The immune response to SARS-CoV-2 varies among patients. We used proteomic analysis to study CD19+ lymphocytes, which are important for the immune response. By comparing the proteomes of CD19+ cells from healthy individuals and COVID-19 patients, we discovered proteins and signaling pathways involve...
ORGANISM(S): Homo sapiens (Human) 
2023-09-24 | PXD042938 | Pride
Cd19+ Human Covid-19 Lymphocytes 
TranscriptomicsEpigenetic changes in B lymphocytes associated with house dust mite allergic asthma.
The increase in atopic diseases has occurred in such a short period of time that it becomes difficult to be attributed only to genetic factors, which usually need more prolonged time periods to manifest. In this setting during the last decade, the science of epigenetics has increasingly developed of...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-26080 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lymphocytes from 1240 Mexican Americans for the discovery of expression QTLs
Transcriptional profiles were generated for lymphocyte samples from 1,240 randomly ascertained, mostly non-diseased Mexican American participants in the San Antonio Family Heart Study. Research findings related to the genetic regulation of expression levels are published in the following article: Go...
ORGANISM(S): Homo sapiens 
2008-01-01 | E-TABM-305 | biostudies-arrayexpress
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