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TranscriptomicsmiRNA-seq data from healthy and DMD human cells, along skeletal muscle differentiation from induced pluripotent stem cells
3 or 4 healthy cells - 3 DMD cells - 7 time points (tissue-derived myoblasts, tissue-derived myotubes, hiPSCs, Day 3 of differentiation, Day 10 of differentiation, Day 17 of differentiation, Day 25 of differentiation).
ORGANISM(S): Homo sapiens 
2020-10-05 | E-MTAB-8293 | biostudies-arrayexpress
TranscriptomicsRNA-seq data from healthy and DMD human cells, along skeletal muscle differentiation from induced pluripotent stem cells
3 healthy cells - 3 DMD cells - 7 time points (tissue-derived myoblasts, tissue-derived myotubes, hiPSCs, Day 3 of differentiation, Day 10 of differentiation, Day 17 of differentiation, Day 25 of differentiation) - 1 replicate per cell line for the tissue-derived samples and 3 biological replicates ...
ORGANISM(S): Homo sapiens 
2020-10-05 | E-MTAB-8321 | biostudies-arrayexpress
TranscriptomicsGene Expression Data for Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease in disease relevant cells, as well as a promising source for cell replacement therapies for degenerative diseases. However one of the crucial limitations before rea...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-29773 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human late passage hiPSCs (pluripotent stem cells)
Detailed analysis comparing induced pluripotent stem cells revealed functional gene expression differences to hESCs that are changed with long term passaging. We used microarrays to detail the changes that are made throughout passaging to hiPSC lines. Experiment Overall Design: hiPSC lines were harv...
ORGANISM(S): Homo sapiens 
2009-07-19 | E-GEOD-16654 | biostudies-arrayexpress
TranscriptomicsCNV analysis for Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease in disease relevant cells, as well as a promising source for cell replacement therapies for degenerative diseases. However one of the crucial limitations before rea...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-29772 | biostudies-arrayexpress
TranscriptomicsExpression data from hESCs, hiPSCs and human fibroblasts.
Detailed analysis comparing hiPSC lines that were newly generated and compared them to already established hiPSC lines We used microarrays to detail various hiPSC lines to confirm faithful reprogramming. hESCs, hiPSCs and human fibroblasts for RNA extraction and hybridization on Affymetrix arrays.
ORGANISM(S): Homo sapiens 
2010-08-06 | E-GEOD-22392 | biostudies-arrayexpress
TranscriptomicsRepeat elements study in pluripotent stem cells [RNA-seq]
We surveyed RNA-Seq data to identify those TEs that are transcriptionally active uniquely in human pluripotent cells. We identified one endogenous retrovirus (HERV-H) family, uniquely found in primates as being unusually abundant in the transcriptome. Poly(A)+ RNA extraction and further sequencing l...
ORGANISM(S): Homo sapiens 
2014-10-09 | E-GEOD-44646 | biostudies-arrayexpress
TranscriptomicsComparison of DNA methylation profilings between hESCs and hiPSCs
It remains controversial whether human induced pluripotent stem cells (hiPSCs) are distinct from human embryonic stem cells (hESCs) in their molecular signatures and differentiation properties. We examined the gene expression and DNA methylation of 49 hiPSC and 10 hESC lines and identified no molecu...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-42448 | biostudies-arrayexpress
TranscriptomicsCGH analyses of human induced pluripotent stem cells
Human induced pluripotent stem cells (hIPSCs) represent a unique opportunity for regenerative medicine since they offer the prospect of generating unlimited quantities of cells for autologous transplantation as a novel treatment for a broad range of disorders. However, the use of hIPSCs in the conte...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-MEXP-3316 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of human iPSC-derived Neural Stem Cells (NSC) from LCA patients and unaffected persons
Our purpose was to investigate genes and molecular mechanisms involved in patients with Leber congenital amaurosis (LCA). Fibroblasts from two unrelated clinically-identified patients (Coriell) were reprogrammed to pluripotency by retroviral transduction. These human induced Pluripotent Stem Cells (...
ORGANISM(S): Homo sapiens 
2015-01-21 | E-GEOD-43924 | biostudies-arrayexpress
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