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MetabolomicsMetabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes
Hypoxic-Ischemic Encephalopathy (HIE) is one of the most relevant contributors to neurological disability in term infants. We hypothesized that clinical outcomes of newborns with (HIE) can be associated with changes at plasma metabolic level enabling the detection of brain injury. Plasma samples of ...
2021-11-09 | MTBLS1041 | MetaboLights
MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (untargeted fecal metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4932 | MetaboLights
MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (targeted SCFA brain metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4933 | MetaboLights
ProteomicsUrinary proteome differences in Hypoxic-Ischemic Encephalopathy newborns
Study utilizes advancements in proteomics technology to analyze urinary protein concentrations, aiming to better understand Hypoxic-Ischemic Encephalopathy brain injury and identify potential therapeutic targets.
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD071111 | Pride
Urine Brain injury Human Newborn 
TranscriptomicsComprehensive gene expression analysis of cerebral cortices from mature rats after neonatal hypoxic-ischemic brain injury
Neonatal hypoxic-ischemic (HI) encephalopathy can lead to severe brain damage and is a common cause of neurological handicaps in adulthood. To elucidate the molecular events occurring in cerebral cortices of mature rats (8 weeks old) after neonatal HI brain insult, we performed comprehensive gene ex...
ORGANISM(S): Rattus norvegicus 
2012-06-27 | E-GEOD-37777 | biostudies-arrayexpress
GenomicsGene expression profile at single cell level from the brain at 3h, 2d, and 7d after hypoxic ischemic encephalopathy
Gene expression profile at single cell level from the brain at 3h, 2d, and 7d after hypoxic ischemic encephalopathy
PRJNA1139835 | ENA
TranscriptomicsGene expression profile at single cell level from the brain at 3h, 2d, and 7d after hypoxic ischemic encephalopathy
Hypoxic ischemic encephalopathy (HIE) causes brain paralysis. Here, we used single-cell RNA sequencing (snRNA-seq) to examine brain cell heterogeneity during the hyperacute (3 h), acute (2 d), and subacute (7 d) phases.
ORGANISM(S): Rattus norvegicus 
2025-06-15 | GSE273044 | GEO
ProteomicsQuieting the Storm: Hypoxia as a Strategy to Boost UC-MSC Therapies for Hypoxic-Ischemic Brain Lesions in Neonatal Rats
Integrating stem cell therapies into clinical settings faces several challenges, particularly in achieving the high cell yields necessary for attaining therapeutic doses. Preconditioning with hypoxic conditions has shown promise in enhancing the mesenchymal stem cells (MSCs)’ reparative capabilities...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-27 | PXD060639 | Pride
Mesenchymal stem cell  brain hypoxia  cell therapy  hypoxic ischemic encephalopathy  preconditioning  proteomics 
TranscriptomicsGene expression changes in the periventricular white matter of neonatal piglets at a defined 48h time point following a hypoxic-ischemic insult: a comparison of piglets left untreated and those treated with a remote post-conditioning stimulus applied to the hind leg immediately after the insult.
Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention whereby brief episodes of ischemia/reperfusion of one organ (limb) mitigate damage in another organ (brain) that has experienced severe hypoxia-ischemia. 16 Large White newborn female piglets were exposed to a tightl...
ORGANISM(S): Sus scrofa 
2016-09-21 | E-MTAB-5125 | biostudies-arrayexpress
UnknownCan we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?
Not available
S-EPMC6585539 | biostudies-literature
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