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MetabolomicsRapid biotransformation of STW 5 constituents by human gut microbiome from IBS- and non-IBS donors

STW 5, a blend of 9 medicinal plant extracts, exhibits promising efficacy in treating functional gastrointestinal disorders, notably irritable bowel syndrome (IBS). Nonetheless, its effects on the gastrointestinal microbiome and the role of microbiota on the conversion of its constituents are sti...

2024-05-07 | MTBLS2398 | MetaboLights
TranscriptomicsGene expression analysis of rectal mucosa in chronic irritable bowel syndrome (IBS) compared to healthy volunteers (HV)
An investigation of gene expression changes in rectal biopsies from donors with IBS compared to controls to begin to understand this complex syndrome. To further investigate differences between IBS groups (constipation and diarrhoea predominant) (part1) and how IBS relates to bacterial infection (pa...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-36701 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of sigmoid colon mucosal biopsies from irritable bowel syndrome patients and healthy control subjects
Irritable bowel syndrome (IBS) is a highly prevalent disorder of the gastrointestinal tract characterized by abdominal pain, bloating, and disturbed bowel function. Here we report on the analysis of microarray expression profiles of sigmoid colon mucosal biopsies from IBS patients and healthy contro...
ORGANISM(S): Homo sapiens 
2007-11-24 | E-TABM-176 | biostudies-arrayexpress
ProteomicsFaecal Proteases and Immune Signatures Drive Subtype-Specific Enteric Neuronal Activation in IBS
Background: Luminal proteases have been implicated in epithelial barrier dysfunction and visceral hypersensitivity in irritable bowel syndrome (IBS), yet their impact on the enteric nervous system (ENS), the principal regulator of gastrointestinal function, remains unknown. We investigated whether ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-10 | PXD071836 | Pride
Protease-activated receptors (pars) Irritable bowel syndrome Serine and cysteine protease activity Faecal supernatant proteomics Luminal–neuronal signalling axis 
GenomicsIBS Costantino
IBS Costantino
PRJEB102380 | ENA
GenomicsMaastricht IBS cohort MIBS
Gut microbiome data of the Maastricht-IBS study
EGAS00001001914 | EGA
GenomicsCorynebacterium singulare strain:IBS B52218
Corynebacterium singulare IBS B52218(T) (=DSM 44357(T)) Genome sequencing
PRJNA246651 | ENA
GenomicsBartonella birtlesii IBS 325
Bartonella birtlesii IBS 325 Genome sequencing and assembly
PRJNA86617 | ENA
GenomicsBartonella alsatica IBS 382
Bartonella alsatica IBS 382 Genome sequencing and assembly
PRJNA75201 | ENA
TranscriptomicsTranscription profiling of human healthy volunteers and IBS patients
Micro-inflammation and gut dysfunction are features of diarrhea-irritable bowel syndrome (d-IBS) patients, although the underlying interacting molecular mechanisms remain mostly unknown. Therefore, we aimed to identify critical networks and signaling pathways active in chronic diarrhea-associated in...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-14841 | biostudies-arrayexpress
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