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GenomicsSynergistic Activation of Inflammatory Cytokine Genes by Priming of Regulatory DNA Elements for Increased Transcription in Response to TLR Signaling
Synergistic activation of inflammatory cytokine genes by IFN-gamma and TLR signaling is important for innate immunity and inflammatory disease pathogenesis, but underlying mechanisms are not known. By obtaining over three billion bases of sequence from chromatin immunoprecipitated DNA, we generated ...
ORGANISM(S): Homo sapiens 
2013-09-20 | E-GEOD-43036 | biostudies-arrayexpress
TranscriptomicsSublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human polymorphonuclear leukocyte gene expression and enhance bactericidal capacity.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are often caused by strains encoding Panton-Valentine leukocidin (PVL). PVL can cause lysis of polymorphonuclear leukocytes (PMNs) and other myeloid cells in vitro, a function considered widely as the primary means...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-33939 | biostudies-arrayexpress
TranscriptomicsInterferon gamma down-regulates miR-3473b to promote macrophage activation
Macrophages are major effector cells and antigen presenting cells of the innate immune system and classical activation of macrophage function requires interferon–γ (IFN-γ) pretreatment (priming) and TLR stimuli, which promotes inflammatory responses though high levels of pro-inflammatory cytokines a...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-50569 | biostudies-arrayexpress
ProteomicsSkin regeneration is enabled in the absence of fibroblast inflammatory priming
Mammalian skin wounds heal by forming fibrotic scars. We report that reindeer antler velvet exhibits regenerative wound healing, whereas identical injury to back skin forms scar. This regenerative capacity was retained following ectopic transplantation of velvet to scar-forming sites. Single-cell mR...
ORGANISM(S): Homo sapiens (Human) 
2023-02-23 | PXD035749 | Pride
Reindeer antler velvet  wound healing  skin regeneration  stromal-immune crosstalk  immune modulation  inflammatory-priming  fibrotic scar  fetal human fibroblasts  myeloid cell maturation  single-cell multi-omics 
GenomicsMulti-scale epigenomic priming of inflammatory genes enables rapid recall in human memory T helper cells [ChIP-seq]
Multi-scale epigenomic priming of inflammatory genes enables rapid recall in human memory T helper cells [ChIP-seq]
PRJNA868704 | ENA
GenomicsMulti-scale epigenomic priming of inflammatory genes enables rapid recall in human memory T helper cells [RNA-seq]
Multi-scale epigenomic priming of inflammatory genes enables rapid recall in human memory T helper cells [RNA-seq]
PRJNA868378 | ENA
GenomicsSkin regeneration is enabled in the absence of fibroblast inflammatory priming
Skin regeneration is enabled in the absence of fibroblast inflammatory priming
PRJNA713822 | ENA
UnknownEstradiol Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese Women.
Not available
S-EPMC4702462 | biostudies-literature
UnknownPro-Inflammatory Priming of the Brain: The Underlying Cause of Parkinson's Disease.
Not available
S-EPMC10178666 | biostudies-literature
UnknownThe roles of regulatory-compliant media and inflammatory/oxytocin priming selection in enhancing human mesenchymal stem/stromal cell immunomodulatory properties.
Not available
S-EPMC11603324 | biostudies-literature
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