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UnknownArchaic chaos: intrinsically disordered proteins in Archaea.
Not available
S-EPMC2880407 | biostudies-literature
ProteomicsRegulation of Src tumor activity by its N-terminal intrinsically disordered region
The membrane anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control active Src conformations. However, Src contains a N-terminal i...
ORGANISM(S): Homo sapiens (Human) 
2022-01-14 | PXD030006 | Pride
Cell transformation Cell signaling Protein kinase Intrinsically disordered region 
UnknownForkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a.
Not available
S-EPMC5314938 | biostudies-literature
ProteomicsMultiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function
Transcription factors harbour defined intrinsically disordered regulatory regions, which raises the question of how they mediate binding to structured co-regulators and how this regulates activity. Here, we present a detailed molecular regulatory mechanism of Forkhead box O4 (FOXO4) by the structure...
ORGANISM(S): Homo sapiens (Human) 
2022-04-15 | PXD026263 | Pride
Foxo signalling Post-translational modification Icat Structural biology Intrinsically disordered proteins Nmr spectroscopy Transcription factors Wnt signalling -catenin Phosphorylation 
ProteomicsIntrinsically Disordered Regions in Chromodomain Helicase DNA-binding (CHD) Proteins Shape Distinct Protein Interaction Networks
Metazoans employ chromodomain helicase DNA-binding (CHD) enzymes to reposition nucleosomal DNA for transcription and replication. The CHD family consists of nine distinct members (CHD1-9) that possess highly conserved chromo and ATPase domains. These domains are flanked by poorly characterised N- an...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD055009 | Pride
Dna helicase Chromatin remodelers Transcription Intrinsically disordered regions Aggregation prone regions Protein-protein interactions 
GenomicsCooperation of a polymerizing SAM domain and an intrinsically disordered region enables full SAMD1 function on chromatin
Cooperation of a polymerizing SAM domain and an intrinsically disordered region enables full SAMD1 function on chromatin
PRJNA1071481 | ENA
GenomicsThe intrinsically disordered AR2 microdomain of RNase E binds mRNA translation initiation regions
The intrinsically disordered AR2 microdomain of RNase E binds mRNA translation initiation regions
PRJNA1415097 | ENA
ProteomicsMolecular basis for the interaction of intrinsically disordered proteins with nuclear PIP2 compartments
Phosphatidylinositol 4,5 bisphosphate (PIP2) is the most abundant eukaryotic nuclear phosphoinositide. PIP2 is found in the nuclear speckles (NS), nucleoli (NL), and nuclear lipid islets (NLIs) and participates in the RNA polymerase II (Pol2) transcription. The formation of phase-separated nuclear s...
ORGANISM(S): Homo sapiens (Human) 
2024-09-30 | PXD045745 | Pride
Ap-ms Pip2 
ProteomicsIntrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity
In development, pioneer transcription factors access silent chromatin to reveal lineage-specific gene programs. The structured DNA-binding domains of pioneer factors have been well characterized, but whether and how low-complexity intrinsically disordered regions (IDRs) affect chromatin and control ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD043586 | Pride
Tcf-1 T-cells L1 Transcription factor Idrs 
ProteomicsThe C-terminal domain of periostin is intrinsically disordered and interacts with 143 proteins in an in vitro epidermal model of atopic dermatitis
Human periostin is a 78-91 kDa alternatively spliced protein belonging to the group of matricellular proteins. The protein has been implicated in extracellular matrix remodeling, tumor development, and metastasis, inflammatory diseases like atopic dermatitis, psoriasis, and asthma. The C-terminal ma...
ORGANISM(S): Homo sapiens (Human) 
2023-09-15 | PXD040164 | Pride
Heparin-binding protein Extracellular matrix protein Periostin Wound healing Connective tissue Protein‐protein interactions Alternative splicing Intrinsically disordered protein Atopic dermatitis 
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