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ProteomicsDevelopment of Cellular Energy Metabolism During Differentiation of Human iPSCs Into Cortical Neurons
We performed label-free quantitative proteomic profiling to characterize metabolic remodeling during early differentiation of human iPSCs into excitatory cortical neurons induced by NGN2 overexpression. Proteomic analysis was conducted at three time-points (iPSCs, day 7, and day 14 post-induction), ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD064787 | Pride
Human Lc-msms Ipscs Cell culture Neurons 
TranscriptomicsRecapitulation of human premature aging by using iPSCs from Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature aging disease1-5, characterized by premature atherosclerosis and degeneration of vascular smooth muscle cells (SMCs)6-8. HGPS is caused by a single-point mutation in the LMNA gene, resulting in the generation of progerin...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-24487 | biostudies-arrayexpress
TranscriptomicsExpression data in induced pluripotent stem cells (iPSCs) derived from a DNA repair deficient fibroblast
Cockayne syndrome (CS) is an autossomal human disorder characterized by premature aging along with other symptoms. At the molecular level, CS is characterized by a deficiency in the Transcription-couple DNA repair pathway caused by a mutation mainly in ERCC6 gene and the absence of its functional pr...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-36648 | biostudies-arrayexpress
ProteomicsGeneration and Proteome Profiling of PBMC-originated, iPSCs-derived Corneal Endothelial Cells
Corneal endothelial cells (CECs) are critical to maintaining clarity of the cornea. This study was initiated to develop peripheral blood mononuclear cells (PBMC)-originated induced pluripotent stem cells (iPSCs)-derived CECs. We isolated PBMC and programmed the mononuclear cells to generate iPSCs. S...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD009142 | Pride
Mass-spectrometry Proteome Ipscs-derived corneal endothelial cells Pbmc 
GenomicsHBV-KMT2B integrated human induced pluripotent stem cells (KMT2B-Int iPSCs) vs heterozygous mutated KMT2B iPSCs (KMT2B-HT iPSCs) vs homozygous mutated KMT2B iPSCs (KMT2B-KO iPSCs) vs their original iPSCs (KMT2B-WT iPSCs)
HBV-KMT2B integrated human induced pluripotent stem cells (KMT2B-Int iPSCs) vs heterozygous mutated KMT2B iPSCs (KMT2B-HT iPSCs) vs homozygous mutated KMT2B iPSCs (KMT2B-KO iPSCs) vs their original iPSCs (KMT2B-WT iPSCs)
PRJNA901875 | ENA
GenomicsGenome-wide maps of Cbx3 in pluripotent mESC and pre-iPSCs
We examined the locations of Cbx3 by chromatin immunoprecipitation in ESCs and pre-iPSCs Examination of Cbx3 in mESC (mouse embryonic stem cells) and pre-iPSCs (fibroblast derived partially reprogrammed cells)
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-44242 | biostudies-arrayexpress
TranscriptomicsHypoxia-enhanced Derivation of iPSCs from Human Dental Pulp Cells
Hypoxia enhances the reprogramming efficiency of human dermal fibroblasts to become induced pluripotent stem cells (iPSCs). Because we showed previously that the hypoxia facilitates the isolation and maintenance of human dental pulp cells (DPCs), we examined here whether it promotes the reprogrammin...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-GEOD-45872 | biostudies-arrayexpress
TranscriptomicsGene expression of human isogenic trisomy 21 induced pluripotent stem cells and derived neurons
Down syndrome (trisomy 21) is the most common genetic cause of intellectual disability, but the precise molecular mechanisms underlying impaired cognition remain unclear. Elucidation of these mechanisms has been hindered by the lack of a model system that contains full trisomy of chromosome 21 (Ts21...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-48611 | biostudies-arrayexpress
GenomicsTranscriptome sequencing study of WT iPSCs and R693Q iPSCs
Transcriptome sequencing study of WT iPSCs and R693Q iPSCs
PRJNA1336138 | ENA
GenomicsThe developmental potential of iPSCs is greatly influenced by the selection of the reprogramming factors (SNEL iPSC and H2A.X deposition pattern)
Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4 and Myc (OSKM) into somatic cells. Though iPSCs are pluripotent, they frequently exhibit high variation in their quality as measured by chimera contribution and tetraploid (4n) complementation. Thus, im...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-55731 | biostudies-arrayexpress
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