ischemia/reperfusion injury

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Mus musculus (411)
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unidentified (6)
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Myocardial ischemia (8)
Acute kidney failure (3)
Ischemia (3)
Brain ischemia (2)
Cardiovascular system disease (2)
Ischaemia reperfusion injury (1)
Normal (1)
Heart injury (1)
Acute myocardial infarction (1)
Chronic kidney disease (1)
Coronary artery disease (1)
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Technology Type

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Gel-based experiment (5)
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EI (1)
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NextSeq 500 (4)
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Illumina HiSeq 2500 (1)
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Illumina HiSeq 4000 (1)
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ZenoTOF 7600 (1)

Publication Date

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2021 (49)
2019 (46)
2020 (34)
2010 (30)
2016 (27)
2015 (23)
2014 (22)
2013 (17)
2011 (16)
2017 (14)
2012 (11)
2008 (11)
2018 (11)
2009 (8)
2007 (8)
2006 (2)
2005 (1)

UNIPROT ID/AC

A0A024RAN2 (1)
A0A087WT59 (1)
A0A087WTX5 (1)
A0A087WVW2 (1)
A0A087WWA5 (1)
A0A087WYL9 (1)
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B7Z556 (1)

ENSEMBL ID

ENSG00000170477 (1)
ENSG00000229353 (1)

CHEBI ID

CHEBI:16919 (8)
CHEBI:16704 (7)
CHEBI:17596 (7)
CHEBI:17368 (7)
CHEBI:15354 (6)
CHEBI:18019 (6)
CHEBI:16737 (6)
CHEBI:7916 (6)
CHEBI:17154 (6)
CHEBI:16335 (6)
CHEBI:17203 (6)
CHEBI:17191 (6)
CHEBI:16414 (6)
CHEBI:16708 (6)
CHEBI:15756 (6)
CHEBI:15891 (6)
CHEBI:17568 (6)
CHEBI:15603 (5)
CHEBI:18211 (5)
CHEBI:16828 (5)
CHEBI:32816 (5)
CHEBI:78320 (5)
CHEBI:17895 (5)
CHEBI:17562 (5)
CHEBI:16235 (5)
CHEBI:16027 (5)
CHEBI:18257 (5)
CHEBI:15741 (5)
CHEBI:16750 (5)
CHEBI:30769 (5)

Metabolite Name

Creatinine (13)
Creatine (11)
Thymine (10)
Adenosine (10)
Taurine (9)
Hypoxanthine (9)
Adenine (9)
Inosine (9)
Uridine (9)
Betaine (9)
Choline (9)
L-Lysine (9)
L-Valine (9)
Uracil (8)
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L-Proline (8)
Ornithine (7)
L-Histidine (7)
L-Tryptophan (7)
Palmitic acid (7)
L-Tyrosine (7)
Pantothenic acid (7)
Guanine (7)
L-Isoleucine (7)
Citrulline (6)
Pyroglutamic acid (6)
L-Leucine (6)
L-Alanine (6)
Xanthine (6)
Guanosine (6)

First Public Date

2024 (145)
2026 (142)
2025 (132)
2023 (80)
2022 (68)
2014 (51)
2021 (47)
2019 (40)
2020 (39)
2017 (13)
2015 (11)
2018 (8)
2016 (7)
2013 (3)

Modelling Approach

Mathematical model (1)
Ordinary differential equation model (1)

Lab affiliation

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (3)
College of Biology, Hunan University, China (2)
Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China (2)
Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (2)
Hubei University of Medicine, Taihe Hospital (2)
King's College London - Cardiovascular Division (2)
Proteomics Core Facility, Sahlgrenska Academy, University of Gothenburg, Sweden (2)
1) Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany 2) CECAD, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands (1)
Biomolecular Mass Spectrometry and Proteomics, BijvoetCenter for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands (1)
Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA (1)
Charles Perkins Centre, University of Sydney (1)
Chengdu University of Traditional Chinese Medicine (1)
Cornell University (1)
Department of Burns and Reconstructive Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China. (1)
Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. (1)
Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, GA, USA. (1)
Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA (1)
Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China (1)
Department of Pharmacology, Harbin Medical University, Heilongjiang 163319, China (1)
Department of Surgery, Maastricht University, Maastricht (1)
Departments of Medicine (Division of Cardiology), Virginia Commonwealth University, Richmond, VA, 23298 (1)
Functional Proteomics Lab. Life Sciences Dept., University of Siena Siena, Italy (1)
ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. Da República, 2780-157 Oeiras, Portugal;iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901, Oeiras , Portugal (1)
ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157, Oeiras, Portugal; iBET- Instituto de Biologia Experimental e Tecnológica, Apartado 12 2780-901 Oeiras, Portugal (1)
Institute of Biochemistry II, Goethe University Medical School, Frankfurt am Main, Germany (1)
Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology (1)
Institute of Model Animal of Wuhan University, Wuhan, China. (1)
Instituto de Investigacion Biomediaca de A Coruna (INIBIC) - Complexo Hospitalario Universitario de A Coruna, A Coruna, SPAIN (1)
King's college London, Cardiovascular Division (1)

IsPrivate

False (2)

Modification

2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (85)
RNA-seq of coding RNA (9)
Unknown experiment type (7)
Transcription profiling by RT-PCR (3)
Animal - High-throughput sequencing (2)
Animal - One-color microarray (1)
High-throughput sequencing (1)
MicroRNA profiling by high throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
ChIP-seq (1)
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RNA-seq of non coding RNA (1)

Release Date

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2011 (83)
2010 (80)
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2008 (34)
2007 (21)
2006 (15)
2005 (10)
2004 (5)
2003 (3)
2002 (3)
1997 (2)
2000 (1)

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Pentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Using a genetically encoded fluorescent indicator, we found that ex...

2026-03-22 | MTBLS14090 | MetaboLights

TRIM47 promotes cardiac ischemia/reperfusion injury

This study shows that TRIM47 is upregulated in cardiomyocytes during cardiac I/R injury in an EGR1-dependent manner, correlating with injury severity. Cardiomyocyte-specific TRIM47 overexpression worsens, while TRIM47 knockout alleviates, I/R-induced cardiac injury and dysfunction. Mechanistically, ...

2026-08-28 | MTBLS14676 | MetaboLights

Pentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

2026-04-13 | MTBLS14264 | MetaboLights

Time-Dependent Gene Profiling Indicates the Presence of Different Phases for Ischemia/Reperfusion Injury in Retina

The purpose of the present study was to investigate time-dependent changes in gene expression, following induction of IR in the rat retina, and to characterize the affected pathways, networks and processes. 6 biological replicates with two treatments (Sham control and Ischemia reperfusion) and 3 tim...

ORGANISM(S): Rattus norvegicus

2013-01-24 | E-GEOD-43671 | biostudies-arrayexpress

CaM Kinase II mediates maladaptive post-infarct remodeling but not acute myocardial ischemia/reperfusion injury

Calcium/calmodulin-dependent protein kinase II (CaMKII) was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. However, the specific functions of the CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury have not been investigated yet. Thus, we studied...

ORGANISM(S): Mus musculus

2014-09-08 | E-GEOD-58486 | biostudies-arrayexpress

RNA-seq of rat myocardial tissue to investigate the cardioprotective mechanism of baicalin in myocardial ischemia-reperfusion injury

This study aimed to investigate the cardioprotective mechanism of baicalin (BAI) against myocardial ischemia-reperfusion injury (MIRI) in rats. We performed RNA-seq on left ventricular myocardial tissue from three groups: Sham (vehicle control), I/R (ischemia-reperfusion injury model), and I/R+BAI (...

ORGANISM(S): Rattus norvegicus

2026-07-31 | E-MTAB-17471 | biostudies-arrayexpress

Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model.

Ischemic stroke triggers severe focal hypoperfusion accompanied with deprivation of oxygen and glucose to the cerebral tissue, together with loss of ATP, depolorization of neurons, elevated extracellular potassium concentration, and subsequently leads to excitotoxicity as well as increased oxidative...

ORGANISM(S): Mus musculus

2011-01-10 | E-GEOD-23160 | biostudies-arrayexpress

Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo mouse model.

This SuperSeries is composed of the following subset Series: GSE23160: Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model. GSE23162: Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo Gpx1 -/- transgenic mouse model. Refer to ...

ORGANISM(S): Mus musculus

2011-01-10 | E-GEOD-23163 | biostudies-arrayexpress

small RNA-Seq of rat kidney in a model of ischemic preconditioning/ischemia-reperfusion injury

Ischemic preconditioning is effective in limiting subsequent ischemic acute kidney injury in experimental models. microRNAs are an important class of post-transcriptional regulator and show promise as biomarkers of kidney injury. An evaluation was performed of the time- and dose-dependent effects o...

ORGANISM(S): Rattus norvegicus

2021-12-31 | E-MTAB-9896 | biostudies-arrayexpress

Exiqon miRCURY microRNA array of rat kidney in a model of ischemic preconditioning/ischemia-reperfusion injury

ORGANISM(S): Rattus norvegicus

2021-12-31 | E-MTAB-9900 | biostudies-arrayexpress

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