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TranscriptomicsA chromatin-modifying function of JNK during stem cell differentiation
Signaling mediates cellular responses to extracellular stimuli. The c-Jun NH2-terminal kinase (JNK) pathway exemplifies one sub-group of Mitogen-activated protein (MAP) kinases, which besides established functions in stress response, also contributes to developmental processes by an unknown mechanis...
ORGANISM(S): Mus musculus 
2011-12-18 | E-GEOD-25532 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomic profiling of HCT116 cells following DHODH and JNK inhibition

Untargeted LC-MS metabolomics was used to investigate metabolic alterations associated with DHODH inhibition and JNK signaling in colorectal cancer. The study included control, DHODH inhibitor treated, JNK inhibitor treated, and combined treatment groups, with pooled quality control samples for a...

2026-08-13 | MTBLS15162 | MetaboLights
TranscriptomicsTranscription profiling of mouse embryonic day 13.5 and 15.5 fetal livers lacking p38alpha, a mitogen-activated kinase that controls inflammatory responses and cell proliferation
The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation. Using mice carrying conditional p38alpha alleles, we investigated its function in postnatal development and tumorigenesis. When p38alpha is specifically deleted in the mouse embryo, fetuses d...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7342 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary human keratinocytes
Oncogenic Ras induces epidermal cell growth arrest. Induction of the JNK/Ap1 signaling cascade by expression of MKK7 overcomes Ras-induced cell growth arrest in a manner dependent on AP1 fucntion. We used microarrays to detail the global programme of gene expression in response to MKK7, Ras activat...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6559 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat aortic smooth muscle cells transfected with dominant negative or upregulated JNK1 and subjected to oxidative stress
Oxidative stress-dependent genes are defined as those induced or suppressed by H2O2 treatement in rat vascular smooth muscle cells. JNK-induced genes in rat vascular smooth muscle cells are defined as those induced by adenoviruses encoding constitutively active MKK7 (caMKK7) + wild type JNK1 (wtJNK1...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2190 | biostudies-arrayexpress
ProteomicsKLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium
The shear stress-induced transcription factor Krüppel-like factor 2 (KLF2) confers anti-inflammatory properties to endothelial cells through inhibition of activator protein 1, presumably by interfering with MAPK cascades. To gain insight into the regulation of these cascades by KLF2, we used antibo...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-19412 | biostudies-arrayexpress
TranscriptomicsOverexpression of c-Jun in mouse Schwann cells of uninjured nerves
Two mouse lines, OE/+ and OE/OE were generated expressing graded elevation (6 fold and 28 fold, respectively) of c-Jun protein selectively in Schwann cells. The effects of this on global gene expression and cellular structure in uninjured nerves was analysed during development and in the adult. Chan...
ORGANISM(S): Mus musculus 
2017-10-16 | E-MTAB-6138 | biostudies-arrayexpress
TranscriptomicsCHIP Analysis - c-Jun/ATF2
Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-1810 | biostudies-arrayexpress
Proteomicsc-JUN interacte with NuRD complex to regulate chromatin remodeling
detect c-JUN interaction proteins in humanembryonic stem cells
ORGANISM(S): Homo Sapiens 
2023-12-28 | PXD048153 |
TranscriptomicsSuppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development
Arterial occlusive diseases are major causes of morbidity and mortality. Blood flow to the affected tissue must be restored quickly if viability and function are to be preserved. Collaterals are artery-to-artery or arteriole-to-arteriole interconnections that can bypass an occlusion by providing an ...
ORGANISM(S): Mus musculus 
2016-08-09 | E-GEOD-71159 | biostudies-arrayexpress
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