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ProteomicsCannabinoid Receptor Type 2 Agonist JWH-133 Stimulates Antiviral Factors and Decreases Proviral, Inflammatory, and Neurotoxic Proteins in HIV-Infected Macrophage Secretome
Although antiviral therapy has improved quality of life, around 50% of people with HIV (PWH) experience neurodegeneration and cognitive decline. This is prompted in part by migration of HIV-infected monocyte-derived macrophages (MDM) to the brain, leading to neuronal death. Previous studies in our l...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD069890 | Pride
Hiv-associated neurocognitive disorders  cb2r  jwh-133  secretome  lc/ms/ms  tmt  proteomics 
ProteomicsQuantitative proteomics reveal that CB2R agonist JWH-133 downregulates NF-κB activation, oxidative stress, and lysosomal exocytosis from HIV-infected macrophages
HIV-associated neurocognitive disorders (HAND) affect 15-55% of HIV-positive patients, with no therapy. HIV-infected monocyte-derived macrophages (MDM) invade the brain of these individuals, promoting neurotoxicity. We demonstrated increased expression of cathepsin B (CATB), a lysosomal protease, in...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048464 | Pride
Proteomics Human Macrophages Neurotoxicity Oxidative stress Hiv Hand Cb2r Cathepsin b 
UnknownThe Potential of JWH-133 to Inhibit the TLR4/NF-κB Signaling Pathway in Uterine Ischemia-Reperfusion Injury.
Not available
S-EPMC11508640 | biostudies-literature
UnknownThe Impact of JWH-133 on Articular Cartilage Regeneration in Osteoarthritis Via Metalloproteinase 13-Dependent Mechanism.
Not available
S-EPMC10589480 | biostudies-literature
UnknownCannabinoid Receptor Type 2 Agonist JWH-133 Stimulates Antiviral Factors and Decreases Proviral, Inflammatory, and Neurotoxic Proteins in HIV-Infected Macrophage Secretome.
Not available
S-EPMC12608856 | biostudies-literature
UnknownQuantitative Proteomics Reveal That CB2R Agonist JWH-133 Downregulates NF-κB Activation, Oxidative Stress, and Lysosomal Exocytosis from HIV-Infected Macrophages.
Not available
S-EPMC10970132 | biostudies-literature
TranscriptomicsCannabinoid Receptor 2 Agonists Attenuate HIV Replication and Inflammatory Activation in HIV-infected Myeloid Cells
Emerging evidence suggests brain-resident myeloid cells, including macrophages and microglia, provide a reservoir for HIV infection in the central nervous system (CNS), and their inflammatory activation is a proposed pathogenic mechanism in HIV-associated neurocognitive disorders (HAND). We investig...
ORGANISM(S): Homo sapiens 
2025-01-22 | GSE250616 | GEO
UnknownAdjuvant Cannabinoid Receptor Type 2 Agonist Modulates the Polarization of Microglia Towards a Non-Inflammatory Phenotype in Experimental Pneumococcal Meningitis.
Not available
S-EPMC7674855 | biostudies-literature
UnknownSuppression of CpG-ODN-mediated IFNα and TNFα response in human plasmacytoid dendritic cells (pDC) by cannabinoid receptor 2 (CB2)-specific agonists.
Not available
S-EPMC7243911 | biostudies-literature
UnknownRole of Cannabinoid Type 2 Receptor Activation in Renal Fibrosis Induced by Unilateral Ureteric Obstruction in Rats.
Not available
S-EPMC10505471 | biostudies-literature
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