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MetabolomicsIntegrated metabolomic and transcriptomic analysis reveals the neurotoxicity and mechanisms of Shengfu Pian

Background: The mechanisms underlying neurological toxicity are complex. Shengfu Pian (SFP), a traditional Chinese medicine, has drawn increasing attention due to its potential neurotoxic effects.

Methods: To investigate the neurotoxic mechanisms of SFP, we first applied non-targeted serum ...

2025-10-11 | MTBLS13086 | MetaboLights
MetabolomicsNeurotoxicity of Propylene Glycol Butyl Ether: Multiomic Evidence from Human BrainSpheres

Exposure to solvents may contribute to the development of neurodevelopmental and neurodegenerative diseases. Glycol ethers consist in a widely used class of organic solvents leading to workers and consumers exposure via many different applications. Ethylene glycol ethers are gradually being repla...

2026-08-25 | MTBLS12921 | MetaboLights
MetabolomicsNeurotoxicity of Propylene Glycol Butyl Ether: Multiomic Evidence from Human BrainSpheres

Exposure to solvents may contribute to the development of neurodevelopmental and neurodegenerative diseases. Glycol ethers consist in a widely used class of organic solvents leading to workers and consumers exposure via many different applications. Ethylene glycol ethers are gradually being repla...

2026-08-25 | MTBLS12771 | MetaboLights
TranscriptomicsPotentiation of neurotoxicity in double mutant mice with Pink1 ablation and A53T-SNCA overexpression
As the second most frequent neurodegenerative disorder of old age, ParkinsonM-bM-^@M-^Ys disease (PD) can result from autosomal dominant causes like increased alpha-synuclein (SNCA) dosage, or from autosomal recessive causes like PINK1 loss-of-function. Interactions between these triggers and their ...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-60414 | biostudies-arrayexpress
TranscriptomicsTDP-43 Neurotoxicity in late D. melanogaster pupae
The aim of this study is to understand the mechanisms of TDP-43 neurotoxicity. Here, we perform a RNA-Seq analysis in TDP-43 gain-of-fucntion (GOF) , TDP-43 loss-of-function and wild-type late pupae heads (73-90 hours APF) and perform TDP-43 GOF vs wild type and TDP-43 LOF vs wild-type differential...
ORGANISM(S): Drosophila melanogaster 
2013-01-22 | E-GEOD-42844 | biostudies-arrayexpress
ProteomicsAcrylamide acute neurotoxicity in adult zebrafish
Acute exposure to acrylamide (ACR), a type-2 alkene, may lead to a ataxia, skeletal muscles weakness and numbness of the extremities in exposed human and laboratory animals. Recently, a zebrafish model for ACR neurotoxicity mimicking most of the pathophysiological processes described in mammalian mo...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-10-19 | PXD008993 | Pride
Neurotoxicity Zebrafish Shotgun proteomics 
ProteomicsModeling acrylamide acute neurotoxicity in zebrafish larvae
Background: Acrylamide (ACR) is a broadly spread neurotoxic chemical of public health concern, as occupational or environmental exposure of humans to ACR may lead to a synaptopathy characterized by ataxia, skeletal muscles weakness and numbness of the extremities. Currently, only the mildly affected...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-10-24 | PXD007169 | Pride
Neurotoxicity Acrylamide Zebrafish model 
TranscriptomicsMonocyte-derived IL-1 and IL-6 are differentially required for cytokine release syndrome and neurotoxicity by CAR-T cells.
Single-cell transcriptome profiling using a 3' droplet-based platform (Chromium,10x Genomics) of human CD45+ leukocytes isolated from leukemic HuSGM3 mice infused with CD19.28z CAR-T cells, two days after cytokine release syndrome (CRS) onset and 5 days later.
ORGANISM(S): Homo sapiens 
2018-05-24 | E-MTAB-6505 | biostudies-arrayexpress
ProteomicsEffects of N-acetylcysteine on the neurotoxicity induced by acute exposure to acrylamide
In this study, we used the adult zebrafish model of ACR acute neurotoxicity for determining the suitability of NAC to protect the brain against ACR toxicity. First, the potential protective effects of NAC on the ACR neurotoxicity were evaluated at the behavioral and molecular (transcriptome and prot...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2020-05-26 | PXD014228 | Pride
Acetylcysteine Acrylamide Neurotoxicity Danio 
ClinicalMonosialotetrahexosylganglioside Sodium Injection for Prevention Neurotoxicity of mFOLFOX 6 in mCRC
The morbidity of colorectal cancer(CRC) is 10%～15% in China.mFolfox6 has become one of the standard regimes for metastatic colorectal cancer (mCRC). Neutropenia and oxaliplatin-induced neurotoxicity are the most common adverse effects which even result in discontinue of chemotherapy, especially for ...
2157874 | ecrin-mdr-crc
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