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TranscriptomicsGene expression response to acrylamide in rat pups
Acrylamide is a type-2 alkene monomer with established human neurotoxic effects. While the primary source of human exposure to acrylamide is occupational, other exposure sources include food, drinking water, and smoking. In this study, neurobehavioral assays coupled with transcriptional profiling ...
ORGANISM(S): Rattus norvegicus 
2012-02-08 | E-GEOD-29004 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse testis following chronic exposure to acrylamide via the drinking water
Acrylamide is a reproductive toxicant that has been detected in foods such as potato chips and breads. The consequences of chronic exposure to acrylamide in the human diet are unknown; however we previously reported that exposure to acrylamide at levels equivalent to human exposure produced high lev...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-47574 | biostudies-arrayexpress
ProteomicsModeling acrylamide acute neurotoxicity in zebrafish larvae
Background: Acrylamide (ACR) is a broadly spread neurotoxic chemical of public health concern, as occupational or environmental exposure of humans to ACR may lead to a synaptopathy characterized by ataxia, skeletal muscles weakness and numbness of the extremities. Currently, only the mildly affected...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-10-24 | PXD007169 | Pride
Neurotoxicity Acrylamide Zebrafish model 
GenomicsEpigenetic effects of acrylamide exposure in mice
Epigenetic effects of acrylamide exposure in mice
PRJNA517706 | ENA
ProteomicsThe reproductive toxicant acrylamide modulates the mouse epididymal proteome to drive alterations to the sperm epigenome and dysregulate embryo development
Paternal exposure to a range of environmental and lifestyle factors elicits distinct changes to the sperm sncRNA profile; modifications that have significant post-fertilization consequences. Despite this knowledge, there remains limited mechanistic understanding of how paternal exposures effect the ...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-07 | PXD022865 | Pride
Small non-protein-coding rna Acrylamide Embryo development Sperm maturation Proteome Epididymis Spermatozoa 
TranscriptomicsGene expression response to acrylamide in rat pups
Acrylamide is a type-2 alkene monomer with established human neurotoxic effects. While the primary source of human exposure to acrylamide is occupational, other exposure sources include food, drinking water, and smoking. In this study, neurobehavioral assays coupled with transcriptional profiling an...
ORGANISM(S): Rattus norvegicus 
2012-02-08 | GSE29004 | GEO
GenomicsThe Role of IL-1beta in acrylamide induced neurotoxicity in mice
The Role of IL-1beta in acrylamide induced neurotoxicity in mice
PRJNA871999 | ENA
TranscriptomicsEpigenetic effects of acrylamide exposure in mice
Acrylamide, a high-production-volume chemical and food contaminant in baked and fried carbohydrate-rich foods has been classified as a “Group 2A carcinogen” (probable human carcinogen) by the IARC. The carcinogenicity of acrylamide is attributed to its well-recognized genotoxicity; however, evidence ...
ORGANISM(S): Mus musculus 
2019-01-30 | GSE125851 | GEO
TranscriptomicsThe Role of IL-1beta in acrylamide induced neurotoxicity in mice
To invistigate the role of IL-1B in acrylamide toxicity in mice, we establish the IL-1B knockdown mice to invistagate if it have a protective effect against acrylamide neurotoxicity
ORGANISM(S): Mus musculus 
2024-01-16 | GSE211746 | GEO
ProteomicsAcrylamide acute neurotoxicity in adult zebrafish
Acute exposure to acrylamide (ACR), a type-2 alkene, may lead to a ataxia, skeletal muscles weakness and numbness of the extremities in exposed human and laboratory animals. Recently, a zebrafish model for ACR neurotoxicity mimicking most of the pathophysiological processes described in mammalian mo...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-10-19 | PXD008993 | Pride
Neurotoxicity Zebrafish Shotgun proteomics 
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