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ProteomicsCB2R loss drives trastuzumab resistance by reorganizing HER2 dimers to evade IFN-γ and enhance EGFR signaling
Despite advances in HER2+ breast cancer treatment, resistance to anti-HER2 therapies remains a significant clinical challenge. This study investigated the role of the endocannabinoid system, specifically the HER2-CB2R heterodimer, in trastuzumab resistance mechanisms. Analysis of human breast cancer...
ORGANISM(S): Homo sapiens (Human) 
2026-05-07 | PXD065700 | Pride
Breast cancer Immunoprecipitation Proteomics Her2 Cb2r 
GenomicsCB2R Agonism Protects Intestinal Epithelium through β-Catenin/HoxA10 Loop in Radiation Injury
CB2R Agonism Protects Intestinal Epithelium through β-Catenin/HoxA10 Loop in Radiation Injury
PRJNA1454815 | ENA
TranscriptomicsCB2R Agonism Protects Intestinal Epithelium through β-Catenin/HoxA10 Loop in Radiation Injury
Background: Radiation-induced intestinal injury (RIII) represents a significant dose-limiting complication of radiotherapy, characterized by substantial loss of intestinal epithelial cells (IECs). While the activation of cannabinoid receptor 2 (CB2R) is protective in immune‑mediated colitis, the int...
ORGANISM(S): Mus musculus 
2026-04-22 | GSE328344 | GEO
GenomicsTransient CB2R Modulation Promotes Luminal-like Differentiation and Restricts Breast Cancer Plasticity
Transient CB2R Modulation Promotes Luminal-like Differentiation and Restricts Breast Cancer Plasticity
PRJNA1470239 | ENA
ProteomicsQuantitative proteomics reveal that CB2R agonist JWH-133 downregulates NF-κB activation, oxidative stress, and lysosomal exocytosis from HIV-infected macrophages
HIV-associated neurocognitive disorders (HAND) affect 15-55% of HIV-positive patients, with no therapy. HIV-infected monocyte-derived macrophages (MDM) invade the brain of these individuals, promoting neurotoxicity. We demonstrated increased expression of cathepsin B (CATB), a lysosomal protease, in...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048464 | Pride
Proteomics Human Macrophages Neurotoxicity Oxidative stress Hiv Hand Cb2r Cathepsin b 
GenomicsTransient CB2R Modulation Promotes Luminal-like Differentiation and Restricts Breast Cancer Plasticity
Cancer cell plasticity enables therapy resistance and metastasis by allowing transitions between stem-like and differentiated states. Differentiation-based strategies aim to stabilize tumor cell identity, yet pharmacological approaches that induce durable lineage restriction remain limited. Here, we...
ORGANISM(S): Mus musculus 
2026-07-30 | GSE333169 | GEO
UnknownActivation of CB2R by synthetic CB2R agonist, PM289, improves brain endothelial barrier properties, decreases inflammatory response and enhances endothelial repair.
Not available
S-EPMC10726734 | biostudies-literature
GenomicsPhysical exercise improves the neuronal function in ischemic stroke via microglial CB2R/P2Y12 signaling
Physical exercise improves the neuronal function in ischemic stroke via microglial CB2R/P2Y12 signaling
PRJNA1117476 | ENA
ProteomicsA selective photoaffinity probe enables assessment of cannabinoid CB2 receptor expression and ligand engagement in human cells
Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression levels and receptor occupancy by small molecules are highly desirable. We report the development of LEI121 as a photoreactive probe to study the type 2 cannabinoid receptor (CB2R), a promising GPCR to treat tissue...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2018-06-15 | PXD008460 | Pride
Target engagement Cb2 receptor Gpcrs Photo-affinity labeling Bio-orthogonal chemistry 
UnknownCB2R activation enhances tumor-associated macrophages-mediated phagocytosis of glioma cell.
Not available
S-EPMC11650289 | biostudies-literature
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