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ProteomicsIdentification of lactate-induced PGK1 K131 lactylation in hepatocellular carcinoma cells
Lactate accumulation is an important metabolic feature of hepatocellular carcinoma and may regulate tumor progression through lactate-dependent post-translational modifications. In this study, we investigated whether lactate-induced protein lactylation contributes to the regulation of phosphoglycera...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD080849 | Pride
Human  hepatocellular carcinoma  hcc  lactate  protein lactylation  lysine lactylation  pgk1  k131  immunoprecipitation  lc-ms/ms  tandem mass spectrometry  post-translational modification 
UnknownPab1 acetylation at K131 decreases stress granule formation in Saccharomyces cerevisiae.
Not available
S-EPMC9867979 | biostudies-literature
ProteomicsIdentification of PD‑1 lysine lactylation sites by immunoprecipitation‑mass spectrometry
This project aims to identify lactylation modification sites on PD‑1 protein. Lactate‑treated MOLT‑4 human T‑lymphoblastic leukemia cells were used for PD‑1 immunoprecipitation, followed by SDS‑PAGE separation and in‑gel digestion. Mass‑spectrometry analysis identified K131 and K135 as major lactyla...
ORGANISM(S): Homo Sapiens 
2026-09-18 | PXD084400 |
UnknownMethylation of CENP-A/Cse4 on arginine 143 and lysine 131 regulates kinetochore stability in yeast.
Not available
S-EPMC10078908 | biostudies-literature
UnknownThe RING-finger ubiquitin E3 ligase TaPIR1 targets TaHRP1 for degradation to suppress chloroplast function.
Not available
S-EPMC11319775 | biostudies-literature
UnknownKeap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals.
Not available
S-EPMC2973898 | biostudies-literature
UnknownA fluorescent protein scaffold for presenting structurally constrained peptides provides an effective screening system to identify high affinity target-binding peptides.
Not available
S-EPMC4118881 | biostudies-literature
UnknownStructural Determinants of Substrate Recognition and Catalysis by Heparan Sulfate Sulfotransferases.
Not available
S-EPMC10550706 | biostudies-literature
UnknownIon permeation through the alpha-hemolysin channel: theoretical studies based on Brownian dynamics and Poisson-Nernst-Plank electrodiffusion theory.
Not available
S-EPMC1304654 | biostudies-literature
ProteomicsCardiomyocyte-derived GPX4 stabilizes BNIP3 to facilitate mitophagy and mitigate myocardial ischemia/reperfusion injury
To elucidate the molecular mechanisms by which GPX4 regulates mitochondrial function, we overexpressed GPX4 in cardiomyocytes and subjected them to hypoxia-reoxygenation (H/R) modeling. Co-immunoprecipitation (Co-IP) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed...
ORGANISM(S): Mus Musculus 
2025-12-22 | PXD072382 |
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