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TranscriptomicsCDK6 as key regulator of hematopoietic and leukemic stem cell activation.
The cyclin-dependent kinases (CDK) CDK6 and CDK4 have redundant functions in regulating cell-cycle progression. We describe a novel role for CDK6 in hematopoietic and leukemic stem cells (HSCs and LSCs) that exceeds its function as cell-cycle regulator. Although hematopoiesis appears regular under s...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-62012 | biostudies-arrayexpress
TranscriptomicsThe important role of GPR84 in MLL leukemogenesis
Beta-catenin signaling is required for establishment of leukemic stem cells (LSCs) in acute myeloid leukemia (AML), yet the upstream regulators that can augment this pathway are unknown. Through genome-wide gene expression analysis and functional studies, we identified an important role for GPR84 in...
ORGANISM(S): Mus musculus 
2014-10-15 | E-MTAB-1932 | biostudies-arrayexpress
TranscriptomicsExpression data of Dnmt1 haploinsufficient leukemia stem cells and bulk leukemia
Leukemia stem cells (LSCs) are an attractive target in treatment of many types of blood cancers. There remains an incomplete understanding of the epigenetic mechanisms driving LSC formation and maintenance, and how this compares to the epigenetic regulation of normal hematopoietic stem cells (HSCs)....
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-31626 | biostudies-arrayexpress
UnknownIdentification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Not available
S-EPMC7921413 | biostudies-literature
ProteomicsExploiting an Epigenetic Resistance Mechanism to PI3 Kinase Inhibition in Leukemic Stem Cells
Acquired non-genetic resistance mechanisms to existing therapies contribute to poor outcomes for acute myeloid leukemia (AML) patients, and inability to target leukemic stem cells (LSCs) can lead to relapse. To overcome these challenges, we tested whether LSCs have dependencies on PI3 kinase. We fou...
ORGANISM(S): Homo sapiens (Human) 
2026-09-18 | PXD050834 | Pride
Leukemia Pi3 Histones Stem cells Epigenetics Kinase 
TranscriptomicsGenome-wide comparison of gene expression level between leukemia stem cells in different tissues
Analysis of gene expression of leukemia stem cells (LSCs) in different tissues. The hypothesis is that the distinct niche in different tissues affects the gene expression of LSCs. Total RNA from LSCs in different tissues including bone marrow (BM), spleen (SPL), peripheral blood (BL), gonadal adipos...
ORGANISM(S): Mus musculus 
2016-07-07 | E-GEOD-81842 | biostudies-arrayexpress
UnknownLong term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells.
Not available
S-EPMC4634876 | biostudies-literature
UnknownLeukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche.
Not available
S-EPMC4938766 | biostudies-literature
UnknownTracking leukemic residuals: dissecting the inverse relationship between CD26+ stem cells and extracellular BCR::ABL1 transcript in Chronic Myeloid Leukemia (CML).
Not available
S-EPMC12641227 | biostudies-literature
TranscriptomicsSCL and LMO1 reprogram thymocytes into self-renewing cells.
The SCL and LMO1 oncogenic transcription factors reprogram thymocytes into self-renewing pre-leukemic stem cells (pre-LSCs). Here we report that SCL directly interacts with LMO1 to activate the transcription of a self-renewal program coordinated by LYL1. Gene expression profiles of thymocytes from S...
ORGANISM(S): Mus musculus 
2015-11-05 | E-GEOD-74659 | biostudies-arrayexpress
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