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MetabolomicsFunctional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming
The axolotl (Ambystoma mexicanum) is a caudate amphibian, which has an extraordinary ability to restore a wide variety of damaged structures by a process denominated epimorphosis. While the origin and potentiality of progenitor cells that take part during epimorphic regeneration are known to ...
2021-11-04 | MTBLS1708 | MetaboLights
TranscriptomicsTranscription profiling of Xenopus hindlimbs during stage-dependent complete and incomplete regeneration
Xenopus laevis tadpoles are capable of limb regeneration following amputation, in a process which initially involves the formation of a blastema. However, Xenopus has full regenerative capacity only through premetamorphic stages. We have used the Affymetrix Xenopus laevis Genome Genechip® microarr...
ORGANISM(S): Xenopus laevis 
2008-06-13 | E-GEOD-4738 | biostudies-arrayexpress
TranscriptomicsComparative Transcriptional Profiling of the Axolotl Limb Identifies a Tripartite Regeneration-Specific Gene Program
Identifying the genetic program that induces limb regeneration in salamanders is an important resource for regenerative medicine, which currently lacks tools to promote regeneration of functional body structures. The genetic network underlying limb regeneration has been elusive due to the complexit...
ORGANISM(S): Ambystoma mexicanum 
2013-01-01 | E-GEOD-36451 | biostudies-arrayexpress
ProteomicsIntegrative analysis of microRNAome, transcriptome, and proteome during the limb regeneration of Cynops orientalis
Salamanders completely regenerate their limbs after amputation. Thus, these animals are unique models to investigate the mechanisms modulating the regeneration in vertebrates. To investigate the influence of microRNAs on the newt limb regeneration, an integrative analysis of microRNAome, transcript...
ORGANISM(S): Cynops Orientalis 
2018-12-17 | PXD012091 |
ProteomicsComparison of Protein Expression During Early Phases of Limb Regeneration Between Regeneration-permissive and Regeneration-deficient Axolotl
In this project, we studied the proteomic profiles of the early stages of blastema formation of neotenic and metamorphic axolotls after limb amputation by means of LC-MS/MS technology. We quantified a total of 714 proteins having an adjusted p < 0.01 with FC greater or equal to 2 between two conditi...
ORGANISM(S): Ambystoma mexicanum 
2019-11-25 | PXD014806 | Pride
Proteomics  axolotl  limb regeneration  metamorphosis  gene expression profile 
MetabolomicsStrontium chelate with Achyranthes bidentata polysaccharide as a carrier promotes bone regeneration through mediating gut-liver-bone axis: The TD chicken model

This study investigates the effect of Achyranthes bidentata polysaccharide-strontium (ABPS-Sr) chelate on tibial dyschondroplasia (TD) in broilers and its underlying mechanisms. TD is a prevalent leg disorder in commercial broilers characterized by reduced angiogenesis in the tibial growth plate ...

2025-09-25 | MTBLS13045 | MetaboLights
MetabolomicsStrontium chelate with Achyranthes bidentata polysaccharide as a carrier promotes bone regeneration through mediating gut-liver-bone axis: The TD chicken model

This study investigates the effect of Achyranthes bidentata polysaccharide-strontium (ABPS-Sr) chelate on tibial dyschondroplasia (TD) in broilers and its underlying mechanisms. TD is a prevalent leg disorder in commercial broilers characterized by reduced angiogenesis in the tibial growth plate ...

2025-09-24 | MTBLS13038 | MetaboLights
TranscriptomicsSingle cell RNA-seq of limb tissue from regeneration-competent, -restricted and -incompetent Xenopus laevis tadpoles
Xenopus laevis tadpoles display a decreasing capacity to regenerate their limbs following injury according to developmental stage. By comparing the regenerative response during the naturally occurring regeneration-competent, -restricted and -incompetent stages, scRNAseq can reveal cell type changes ...
ORGANISM(S): Xenopus laevis 
2021-05-17 | E-MTAB-9104 | biostudies-arrayexpress
TranscriptomicsDifferential microRNA Expression during Muscle Regeneration
MicroRNAs (miRNAs) are important in the regulation of many biological processes including muscle development. However, little is known regarding miRNA regulation of muscle regeneration. In mature murine tibialis anterior muscle following injury, 298 miRNAs were significantly changed during the time ...
ORGANISM(S): Mus musculus 
2012-04-24 | E-GEOD-37479 | biostudies-arrayexpress
GenomicsMouse embryo limb bud regeneration
Mouse embryo limb bud regeneration
PRJNA1241699 | ENA
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