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MetabolomicsTetrandrine regulates NAADP-mediated calcium signalling 1 through a novel LIMP-2-dependent, sphingosine-mediated mechanism.
Tetrandrine (Tet) is an highly potent inhibitor of Ebola virus replication by blocking NAADP51 dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent. Using a clickable, photoaffinity probe of Tet, we identified lysosomal integral membrane p...
2025-05-23 | MTBLS12492 | MetaboLights
ProteomicsTetrandrine regulates NAADP-mediated calcium signalling by a novel LIMP-2-dependent, sphingosine-mediated mechanism
Tetrandrine (Tet) is a highly potent inhibitor of Ebola virus replication by blocking NAADP-dependent calcium release through endolysosomal two-pore channels (TPCs) and is a moderately potent anti-tumor agent. Using a clickable, photoaffinity probe of Tet, we identified lysosomal integral membrane p...
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD064455 | Pride
Tetrandrine  limp-2  sphingosine-mediated mechanism  proteomics 
GenomicsTetrandrine regulates NAADP-mediated calcium signalling through a novel LIMP-2-dependent, sphingosine-mediated mechanism
Tetrandrine regulates NAADP-mediated calcium signalling through a novel LIMP-2-dependent, sphingosine-mediated mechanism
PRJNA876411 | ENA
TranscriptomicsTetrandrine regulates NAADP-mediated calcium signalling through a novel LIMP-2-dependent, sphingosine-mediated mechanism
Tetrandrine (Tet) is a highly potent inhibitor of Ebola virus replication by blocking NAADP-dependent calcium release through endolysosomal two-pore channels (TPCs) and is a moderately potent anti-tumor agent. Using a clickable, photoaffinity probe of Tet, we identified lysosomal integral membrane p...
ORGANISM(S): Homo sapiens 
2023-03-04 | GSE212648 | GEO
TranscriptomicsTranscription profiling of rat Ren2 left ventricles to generate predictive heart failure expression profile
The intercalated disc of cardiac myocytes is emerging as a crucial structure in the heart. Loss of intercalated disc proteins like N-cadherin causes lethal cardiac abnormalities, mutations in intercalated disc proteins cause human cardiomyopathy. A comprehensive screen for novel mechanisms in failin...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-4286 | biostudies-arrayexpress
UnknownLysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.
Not available
S-EPMC6684646 | biostudies-literature
UnknownLIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance.
Not available
S-EPMC4217458 | biostudies-literature
UnknownCryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2.
Not available
S-EPMC11955523 | biostudies-literature
UnknownLysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor.
Not available
S-EPMC4104448 | biostudies-literature
UnknownA Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology.
Not available
S-EPMC6700557 | biostudies-literature
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