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MetabolomicsTetrandrine regulates NAADP-mediated calcium signalling 1 through a novel LIMP-2-dependent, sphingosine-mediated mechanism.
Tetrandrine (Tet) is an highly potent inhibitor of Ebola virus replication by blocking NAADP51 dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent. Using a clickable, photoaffinity probe of Tet, we identified lysosomal integral membrane p...
2025-05-23 | MTBLS12492 | MetaboLights
ProteomicsTetrandrine regulates NAADP-mediated calcium signalling by a novel LIMP-2-dependent, sphingosine-mediated mechanism
Tetrandrine (Tet) is a highly potent inhibitor of Ebola virus replication by blocking NAADP-dependent calcium release through endolysosomal two-pore channels (TPCs) and is a moderately potent anti-tumor agent. Using a clickable, photoaffinity probe of Tet, we identified lysosomal integral membrane p...
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD064455 | Pride
Tetrandrine  limp-2  sphingosine-mediated mechanism  proteomics 
ProteomicsTetrandrine-Driven Autophagy Suppresses SARS-CoV-2 Replication by Modulating Cholesterol and IGF Signaling Pathways: A Proteomic Analysis
In this project expression proteomics of lung epithelia cells (Calu-3) was performed. Cells were either left untreated, or treated with 5 microM or 10 microM of Tetrandrine, in the absence or presence of SARS-CoV-2 infection.
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD064448 | Pride
Lung Lc-msms Expression proteomics Virus 
GenomicsTetrandrine regulates NAADP-mediated calcium signalling through a novel LIMP-2-dependent, sphingosine-mediated mechanism
Tetrandrine regulates NAADP-mediated calcium signalling through a novel LIMP-2-dependent, sphingosine-mediated mechanism
PRJNA876411 | ENA
UnknownInhibition of autophagy induced by tetrandrine promotes the accumulation of reactive oxygen species and sensitizes efficacy of tetrandrine in pancreatic cancer.
Not available
S-EPMC11238362 | biostudies-literature
UnknownTetrandrine Inhibits Skeletal Muscle Differentiation by Blocking Autophagic Flux.
Not available
S-EPMC9331307 | biostudies-literature
UnknownSynthesis, biological evaluation and toxicity of novel tetrandrine analogues.
Not available
S-EPMC7473156 | biostudies-literature
UnknownTetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.
Not available
S-EPMC8645995 | biostudies-literature
UnknownMechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology.
Not available
S-EPMC8275110 | biostudies-literature
UnknownTetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.
Not available
S-EPMC5715583 | biostudies-literature
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