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MetabolomicsA lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Human plasma assay)
Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were as...
2018-03-13 | MTBLS616 | MetaboLights
MetabolomicsA lipidomic human population and translational feeding study of hepatic steatosis and de novo lipogenesis (Murine liver assay)
Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were as...
2018-03-12 | MTBLS614 | MetaboLights
TranscriptomicsHNF1-alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP1 & ChREBP activation
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1a (HNF1a), were identified in 50% of hepatocellular adenomas (HCA) phenotypically characterized by a striking steatosis. To understand the molecular basis of this aberrant lipid storage, w...
ORGANISM(S): Homo sapiens 
2007-05-01 | E-GEOD-7473 | biostudies-arrayexpress
ProteomicsFASN-dependent de novo lipogenesis is required for brain development
Fate and behaviour of neural progenitor cells is tightly regulated during mammalian brain development. Metabolic pathways, such as glycolysis and oxidative phosphorylation, that are required for supplying energy and providing molecular building blocks to generate cells, govern progenitor function. H...
ORGANISM(S): Homo sapiens (Human) 
2022-01-14 | PXD026110 | Pride
Fasn Human Mouse Lipogenesis Brain development Brain organoids 
TranscriptomicsAltered de novo lipogenesis contributes to low adipose stores in cystic fibrosis mice.
Cystic fibrosis (CF) mouse models exhibit exocrine pancreatic function yet do not develop adipose stores to the levels of non-CF mice. CF mice homozygous for the Cftr mutation (F508del) at 3 weeks (post-weaning) and 6 weeks (young adult) of age had markedly less adipose tissue than non-CF mice. Both...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-33319 | biostudies-arrayexpress
ProteomicsSOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in HCC
SOCS5 stimulate the promoter of SREBP1 to induce de novo lipogenesis to promote HCC metastasis
ORGANISM(S): Homo Sapiens 
2024-01-22 | PXD048740 |
TranscriptomicsIntegrated Control of Hepatic Lipogenesis vs. Glucose Production Requires FoxO Transcription Factors
Insulin integrates hepatic glucose and lipid metabolism, directing nutrients to storage as glycogen and triglyceride. In type 2 diabetes, levels of the former are low and the latter are exaggerated, posing a pathophysiologic and therapeutic conundrum. A branching model1 of insulin signaling, with Fo...
ORGANISM(S): Mus musculus 
2014-08-20 | E-GEOD-60527 | biostudies-arrayexpress
GenomicsHuman BRD2 impedes pluripotency reprogramming mainly by suppressing lipogenesis
Human BRD2 impedes pluripotency reprogramming mainly by suppressing lipogenesis
PRJNA1303186 | ENA
TranscriptomicsMetabolic control of adult neural stem cell activity by FASN-­dependent lipogenesis
Mechanisms controlling the proliferative activity of neural stem/progenitor cells (NSPCs) play a pivotal role to ensure life-long neurogenesis in the mammalian brain. How metabolic programs are coupled with NSPC activity remains unknown. Here we show that fatty acid synthase (FASN), the key enzyme o...
ORGANISM(S): Mus musculus 
2012-11-02 | E-GEOD-27391 | biostudies-arrayexpress
TranscriptomicsExpression of Splicing Factor Genes is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis
Alternative mRNA splicing provides transcript diversity and has been proposed to contribute to several human diseases. Here, we demonstrate that expression of genes regulating RNA processing is decreased in both liver and skeletal muscle of obese humans. To determine the metabolic impact of reduced ...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-22435 | biostudies-arrayexpress
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