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ProteomicsNanoparticle-enabled plasma proteomics of a preclinical atherosclerosis model reveals common signatures with human disease
Coronary heart disease (CHD) accounts for one-third of deaths in the United States, with an annual economic burden exceeding $400 billion. Elevated plasma levels of low-density lipoprotein-cholesterol (LDL-C) is a major risk factor for CHD, through its promotion of atherosclerosis. Mutations in the ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD063218 | Pride
Plasma Atherosclerosis Dia Nanoparticle Proteomics 
ProteomicsCryo-Electron Microscopy Shows Absence of Conventional Protein Corona on Lipid Nanoparticle Surfaces
Upon exposure to biological fluids, nanoparticles rapidly acquire a “protein corona”, a layer of adsorbed biomolecules, predominantly proteins. This layer significantly impacts nanoparticle pharmacokinetics and biodistribution, making detailed characterization vital for designing safe, and targeted ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD070622 | Pride
Cryo-tem Lipid nanoparticles Protein corona Extracellular vesicles Corona shell Fusion 
GenomicsGenome-wide forward genetic screening to identify receptors and proteins mediating nanoparticle uptake and intracellular processing
Nanoparticle uptake screen
PRJEB71925 | ENA
UnknownA saposin-lipoprotein nanoparticle system for membrane proteins.
Not available
S-EPMC4894539 | biostudies-literature
UnknownA statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation.
Not available
S-EPMC4001802 | biostudies-literature
ProteomicsMultiomics analysis of naturally efficacious LNP coronas reveals high-density lipoprotein is necessary for LNP function. VLDLHDL corona
The MS data set contains the result from HDL VLDL corona used in the publication, titled Multiomics analysis of naturally efficacious LNP coronas reveals high-density lipoprotein is necessary for LNP function.
ORGANISM(S): Homo sapiens (Human) 
2023-06-07 | PXD041944 | Pride
Vldl hdl corona 
ProteomicsMultiomics analysis of naturally efficacious LNP coronas reveals high-density lipoprotein is necessary for LNP function. Rat Plasma
The MS data set contains the result from each individual rat plasma used in the publication, titled Multiomics analysis of naturally efficacious LNP coronas reveals high-density lipoprotein is necessary for LNP function.
ORGANISM(S): Rattus norvegicus (Rat) 
2023-06-07 | PXD041925 | Pride
Rat plasma 
ProteomicsMultiomics analysis of naturally efficacious LNP coronas reveals high-density lipoprotein is necessary for LNP function. Individual corona
The MS data set contains the result from each individual rat plasma derived corona used in the publication, titled Multiomics analysis of naturally efficacious LNP coronas reveals high-density lipoprotein is necessary for LNP function.
ORGANISM(S): Rattus norvegicus (Rat) 
2023-06-07 | PXD041938 | Pride
Lnp corona 
UnknownHigh-Density Lipoprotein Nanoparticle Imaging in Atherosclerotic Vascular Disease.
Not available
S-EPMC6113536 | biostudies-literature
UnknownLipid nanoparticle delivery of TALEN mRNA targeting LPA causes gene disruption and plasma lipoprotein(a) reduction in transgenic mice.
Not available
S-EPMC11764125 | biostudies-literature
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