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GenomicsLocal Translation in Nuclear Condensate Amyloid-bodies
Local Translation in Nuclear Condensate Amyloid-bodies
PRJNA692199 | ENA
ProteomicsLocal RNA translation controls cell migration and Rab GTPase function
Numerous RNAs exhibit specific distribution patterns in mammalian cells. However, the functional and mechanistic consequences are relatively unknown. We investigate here the functional role of RNA localization at cellular protrusions of mesenchymal migrating cells, using as a model the RAB13 RNA, wh...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-01 | MSV000085883 | MassIVE
ProteomicsLocal translation of mitochondrial proteins at the synapse
To systematically explore the dynamics of the synaptic proteome upon neuronal stimulation we employed a simple model system which is based on isolated synaptoeurosomes (SN). Synaptoneurosomes are preparations freshly obtained from the brain and enriched in synapses, containing both pre and postsyna...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-12 | PXD012707 | Pride
Local translation Synaptosomes Quantitative proteomics 
ProteomicsLocal translation of mitochondrial proteins at the synapse, LFQ expriment
To systematically explore the dynamics of the synaptic proteome upon neuronal stimulation we employed a simple model system which is based on isolated synaptoeurosomes (SN). Synaptoneurosomes are preparations freshly obtained from the brain and enriched in synapses, containing both pre and postsyna...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-12 | PXD012746 | Pride
Local translation Synaptosomes Quantitative proteomics 
TranscriptomicsImproved transcription and translation with L-leucine stimulation of mTORC1
Roberts syndrome (RBS) is a human developmental disorder caused by mutations in the cohesin acetyltransferase ESCO2. We previously reported that mTORC1 was inhibited and overall translation was reduced in RBS cells. Treatment of RBS cells with L-leucine partially rescued mTOR function and protein sy...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-64962 | biostudies-arrayexpress
GenomicsAxonal ER tubules control local translation via P180/RRBP1-mediated ribosome interactions
Axonal ER tubules control local translation via P180/RRBP1-mediated ribosome interactions
PRJNA1090922 | ENA
ProteomicsAltered mRNA transport and local translation in iNeurons with RNA binding protein knockdown
Neurons rely on mRNA transport and local translation to facilitate rapid protein synthesis in processes far from the cell body. These processes allow precise spatial and temporal control of translation and are mediated by RNA binding proteins (RBPs), including those known to be associated with neuro...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD054548 | Pride
Human Ipsc derived ineurons 
GenomicsAltered mRNA transport and local translation in i3Neurons with RNA binding protein knockdown
Altered mRNA transport and local translation in i3Neurons with RNA binding protein knockdown
PRJNA1273942 | ENA
TranscriptomicsFunctionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience
The subcellular localization and translation of messenger RNA (mRNA) supports functional differentiation between cellular compartments. In neuronal dendrites, local translation of mRNA provides a rapid and specific mechanism for synaptic plasticity and memory formation, and might be involved in the ...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-58343 | biostudies-arrayexpress
ProteomicsProtrusion vs Cell-body pulsed-SILAC proteomics
In mesenchymal-like cell migration, cells need to polarise into a protrusive front and a retracting cell body. Apart from proteins, several mRNAs are known to be localised to cell protrusions but to what extent RNA localisation and local translation contributes toward front-back assymetry is unknown...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2015-10-09 | PXD002649 | Pride
Pulsed-silac  local translation  protrusion 
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