Synaptosomes - OmicsDI

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PS 22:6-22:1 (1)
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Lab affiliation

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Paracelsus Private Medical University, Salzburg, Austria (2)
Molecular Physiology of the Synapse Laboratory Institut de Recerca Sant Pau (IR Sant Pau) C/Sant Quintí, 77-79 08041 Barcelona Spain (2)
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Max Planck Institute of Psychiatry, Munich, Germany Biomedical Center, Molecular Biology, Ludwig-Maximilians-Universitat, Munich, Germany (1)
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The Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine USA (1)
Neurology Department, Experimental Research in Stroke and Inflammation (ERSI) group, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (1)
Synapse Proteomics Group, Children's Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia (1)
Ruhr-University Bochum, Zentrum für Proteindiagnostik (ProDi), Medizinisches Proteom-Center (MPC) (1)
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National Institute of Mental Health and Neurosciences (1)
Chemistry and biochemistry, University of Windsor, Canada (1)
Cologne Excellence Cluster Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany (1)
University of Vienna Department of Chemistry Institute of Analytical Chemistry (1)
Bernstein Professor Emeritus in Adult Psychiatry Department of Psychiatry and Behavioral Sciences University of Minnesota Medical School Minneapolis, Minnesota, USA (1)
Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Str 10, 13125 Berlin (1)
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Centre for Regenerative Medicine School of Biological Sciences University of Edinburgh 5 Little France Drive Edinburgh, EH16 4UU UK (1)
Department of Molecular Biophysics and Biochemistry, Yale University, Keck MS & Proteomics Resource at Yale. (1)
Laboratory of Cell Biophysics, Nencki Institute of Experimental Biology,Polish Academy of Sciences, Warsaw, Poland (1)
Room 6313, Academic building, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon (1)
Institute of Clinical Chemistry, University Medical Center Goettingen, 37075 Goettingen, Germany; Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany (1)
Duke Proteomics and Metabolomics Shared Resource (1)

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Protein phosphorylation in depolarized synaptosomes

Rat brain synaptosomes were used to study effects of calcium and synaptic vesicle cycling on protein phosphorylation following potassium chloride-induced depolarization.

ORGANISM(S): Homo sapiens (Human) Clostridium botulinum A str. Hall Rattus norvegicus (Rat)

2021-02-17 | PXD020564 | Pride

Aging synaptosomes

PRJNA1183877 | ENA

Proteomic analysis of cerebellar synaptosomes in presymptomatic cystatin B –deficient mice

Loss-of-function mutations in cystatin B (CSTB) cause progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1). Cstb-deficiency in mice leads to early alterations in GABAergic signaling, and causes neuroinflammation followed by progressive neurodegeneration, manifesting as progressive myocl...

ORGANISM(S): Mus musculus (Mouse)

2020-10-20 | PXD019370 | Pride

Cystatin b Cerebella Mouse Synaptosome Lc-esi-ms/ms

Proteomic characterization of synaptosomes from human substantia nigra indicates altered mitochondrial translation in Parkinson’s disease

Parkinson´s disease (PD) feature a progressive degeneration of dopaminergic neurons in the substantia nigra (SN). Additionally, numerous studies indicate an altered synaptic function during the course of PD. In order to characterize the proteome of synaptosomes isolated from the substantia nigra and...

ORGANISM(S): Homo sapiens (Human)

2021-06-07 | PXD022092 | Pride

Parkinson's disease Mass spectrometry Subcellular fractionation

Transcription profiling of rat synaptosomes of the hippocampus vs. total hippocampus reveals activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites

Mammalian target of rapamycin (mTOR) is implicated in synaptic plasticity and local translation in dendrites. Here we found that the mTOR inhibitor, rapamycin, increased the Kv1.1 voltage-gated potassium channel protein in hippocampal neurons and promoted Kv1.1 surface expression on dendrites withou...

ORGANISM(S): Rattus norvegicus

2008-06-13 | E-GEOD-5516 | biostudies-arrayexpress

Calcium-triggered (de)ubiquitination events in depolarized synaptosomes

Neurons communicate at synapses through the release of neurotransmitters (NT). These NTs are stored in synaptic vesicles (SVs) at the presynaptic nerve terminal, where they undergo a trafficking cycle consisting of Ca2+-triggered SV exocytosis, SV endocytosis and regeneration. While protein phosphor...

ORGANISM(S): Rattus norvegicus (Rat)

2025-04-18 | PXD052826 | Pride

Lc-msms Synaptosomes Rat Tmt Prm Camkiia Ubiquitin Dda

Proteomic characterization of synaptosomes and sarkosyl-insoluble protein inclusions from Alzheimer's disease patients

Alzheimer’s disease is characterized by neuropathological accumulation of amyloid plaques and neurofibrillary tangles composed of amyloid-beta peptides and hyperphosphorylated tau protein, respectively. These neuropathological changes alter the function of neurons, including synaptic contacts betwee...

ORGANISM(S): Homo sapiens (Human)

2026-07-09 | PXD070075 | Pride

Human Synaptosomes Brain Alzheimer's disease Sarkosyl-insoluble fraction

Transcriptome analysis of synaptosomes in ageing

PRJNA1183882 | ENA

Synaptosomes: new vesicles for neuronal mitochondrial transplantation.

Not available

S-EPMC7789323 | biostudies-literature

RNAs associated with ribosomes in aging synaptosomes

PRJNA1183883 | ENA

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