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MetabolomicsMass spectrometry imaging of phosphatidylcholine metabolism in lungs administered with therapeutic surfactants and isotopic tracers

Mass spectrometry imaging (MSI) visualises molecular distributions throughout tissues but is blind to dynamic metabolic processes. Here, MSI with high mass resolution together with multiple stable isotope labelling provided spatial analyses of phosphatidylcholine (PC) metabolism in mouse lungs. D...

2020-10-30 | MTBLS2075 | MetaboLights
MetabolomicsQuantification of ω-3 fatty acids and their derivatives in lungs from hypoxia-induced pulmonary hypertension (PH) mice.
Not available
ORGANISM(S): Mus musculus 
ST001951 | MetabolomicsWorkbench
ProteomicsProteomics of necrotic granulomas in lungs of C3HeB/FeJ mice infected with M. tuberculosis
C3heB/FeJ mice were infected with M. tuberculosis to form necrotic granulomatous lesions. FFPE samples of infected lungs with granulomas were microdissected into three distinct regions, Caseum, foamy macrophage, and Cell. Proteins were extracted from microdissected samples, followed by LC-MS/MS.
ORGANISM(S): Mus Musculus (mouse) 
2022-09-06 | PXD030088 | JPOST Repository
TranscriptomicsGene Expression Analysis of Host Immune Responses in CD11b positive cells isolated from lungs of the UV inactivated SARS-CoV-immunized mice following Lethal SARS-CoV Infection
To better understand the biological pathways by which UV inactivated SARS-CoV-induced pulmonary eosinophilia occurs, we examined global transcriptional changes in macrophages from the lungs of mouse. Female BALB/c mice were used at 21 weeks of age. Mice were subcutaneously immunized with UV inactiv...
ORGANISM(S): Mus musculus 
2014-05-22 | E-GEOD-50855 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of mRNA from lungs of WT and Pglyrp1-/- mice sensitized with HDM
Wild type (WT) and Pglyrp1-/- mice were treated with PBS or sensitized 5 days/week for 3 or 5 weeks with 10 M-BM-5l per application of 2.5 mg/ml of purified house dust mite allergen. 3 days after the last sensitization the lungs were removed and homogenized, and RNA was isolated from the right lobes...
ORGANISM(S): Mus musculus 
2012-12-25 | E-GEOD-43137 | biostudies-arrayexpress
TranscriptomicsAcquired chromosome abnormalities in the lungs of patients with Pulmonary Arterial Hypertension (Illumina)
Vascular remodeling in pulmonary arterial hypertension (PAH) involves proliferation and migration of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Previous studies have indicated that the endothelial cell proliferation is quasi-neoplastic, with evidence of monoclonal...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-GEOD-21097 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lungs of C3H mice infected with Bordetella and mock control
Transcriptional responses in lungs of C3H mice infected with Bordetella and mock control
ORGANISM(S): Mus musculus 
2007-05-11 | E-TABM-266 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lungs from SCID and wild type mice infected with L3 stage infectious Nippostrongylus brasiliensis to examine the innate immune response to helminth infection in the lung.
The goal of this experiment was to examine the innate immune response to helminth infection in the lung. Hookworms (like many other helminths) use an obligate migration pathway through the lung. Their infection has been characterized in the gut in detail, but early immune responses in the lung have ...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3414 | biostudies-arrayexpress
TranscriptomicsChoriodecidual Infection Downregulates Angiogenesis and Morphogenesis Pathways in Fetal Lungs from Macaca Nemestrina
Intrauterine exposure to amniotic fluid (AF) cytokines is thought to predispose to bronchopulmonary dysplasia (BPD). We evaluated the effects of GBS exposure on RNA expression in fetal lung tissue to determine early molecular pathways associated with fetal lung injury that may progress to BPD. Ten ...
ORGANISM(S): Macaca nemestrina 
2013-04-23 | E-GEOD-39029 | biostudies-arrayexpress
TranscriptomicsFgf8 E18.5 hypomorph versus control mouse fetal lungs
We set out to look for genome wide gene expression changes due to deficiency of Fgf8 in the lung. RNA from 3 lungs from each genotype (mutant and littermate wild type control) are pooled for each cDNA synthesis and hybridized to individual array for a quadruple biologic repeat of the experiment
ORGANISM(S): Mus musculus 
2010-09-20 | E-GEOD-22893 | biostudies-arrayexpress
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