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ProteomicsANP32B is a macroh2A histone chaperone
Interaction proteomics in cell extracts on tagged macroH2A, either expressed in cells or using recombinant dimers with H2B.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD045696 | Pride
Anp32b Histone chaperone Human Macroh2a 
GenomicsMacro histone variants preserve cell identity by preventing the gain of H3K4me2 during reprogramming
Transcription factor-induced reprogramming of somatic cells to pluripotency is a very inefficient process, probably due to the existence of important epigenetic barriers that are imposed during differentiation and that contribute to preserve cell identity. In an effort to decipher the molecular natu...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-44400 | biostudies-arrayexpress
GenomicsPurification of macroH2A.1 and macroH2A.2 Nucleosomes from Fetal Mouse Liver
MacroH2As core histone variants have a unique structure that includes C-terminal nonhistone domain. MacroH2As are highly conserved in vertebrates, and are thought to regulate gene expression. However the nature of genes regulated by macroH2As and the biological significance of macroH2As for the orga...
ORGANISM(S): Mus musculus 
2014-10-15 | E-GEOD-57796 | biostudies-arrayexpress
TranscriptomicsExpression data from macroH2A shRNA lines
Cancer is a disease of both genetic and epigenetic changes. While increasing evidence demonstrates that oncogenic progression entails chromatin-mediated changes such as DNA methylation, the role of histone variants in cancer initiation and progression currently remains unexplored. Here, we report th...
ORGANISM(S): Mus musculus 
2010-12-23 | E-GEOD-19181 | biostudies-arrayexpress
UnknownMice without macroH2A histone variants.
Not available
S-EPMC4248737 | biostudies-literature
GenomicsPurification of macroH2A.1 and macroH2A.2 Nucleosomes from Fetal Mouse Liver
MacroH2As core histone variants have a unique structure that includes C-terminal nonhistone domain. MacroH2As are highly conserved in vertebrates, and are thought to regulate gene expression. However the nature of genes regulated by macroH2As and the biological significance of macroH2As for the orga...
ORGANISM(S): Mus musculus 
2014-10-15 | GSE57796 | GEO
UnknownLSH mediates gene repression through macroH2A deposition.
Not available
S-EPMC7648012 | biostudies-literature
GenomicsFACT-mediated depletion of macroH2A-nucleosome regulates the cell response of macrophage
FACT-mediated depletion of macroH2A-nucleosome regulates the cell response of macrophage
PRJNA1045692 | ENA
GenomicsFACT-mediated depletion of macroH2A-nucleosome regulates the cell response of macrophage
FACT-mediated depletion of macroH2A-nucleosome regulates the cell response of macrophage
PRJNA1044766 | ENA
GenomicsThe histone variant macroH2A modulates inflammatory response in cancer [HepG2]
The histone variant macroH2A modulates inflammatory response in cancer [HepG2]
PRJNA679723 | ENA
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