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TranscriptomicsTranscription profiling of injured retinas from male Sprague-Dawley rats at 4 hours, 1, 3, 7 and 30 days post-injury
Sprague-Dawley rat retina post-injury and control samples
ORGANISM(S): Rattus norvegicus 
2007-10-26 | E-GEOD-1001 | biostudies-arrayexpress
ProteomicsProteomics-Based Retinal Target Engagement Analysis and Retina-Targeted Delivery of 17β-Estradiol by the DHED Prodrug in Males. Katalin Prokai-Tatrai,* Khadiza Zaman, Vien Nguyen, Daniel L. De La Cruz and Laszlo Prokai
We examined the impact of 17β-estradiol (E2) eye drops on the modulation of the proteome pro-file in the male rat retina. With discovery-driven proteomics, we have identified proteins that were regulated by the treatment. These proteins were assembled to several bioinformatics-based networks implica...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-11-04 | PXD027902 | Pride
Prote-omics Isotope-dilution Targeted proteomics Dhed prodrug Neuroprotection  lc-ms/ms 17β-estradiol  e2  eye drops  male retina  parallel-reaction monitoring 
MetabolomicsOral ketone monoester ingestion reduces circulating blood glucose, exogenous carbohydrate oxidation and oxidation efficiency in trained male cyclists when fed 120 g of CHO per hour during exercise

We examined the effects of ketone monoester (KME) and carbohydrate (CHO) co-ingestion on exogenous CHO oxidation, metabolomic responses and exercise capacity. In a randomised repeated-measures design (after a 36 h CHO loading protocol and pre-exercise meal of 12 and 2 g.kg-1, respectively), eight...

2026-04-22 | MTBLS6260 | MetaboLights
ProteomicsThe Comprehensive Mouse Retina PhosphoProteome
Diverse groups of proteins play integral roles in both the physiology and pathophysiology of the mouse retina. A comprehensive mouse retina phosphoproteome has been developed using a discovery-based proteomic approach in conjunction with an enrichment procedure for phosphopeptides.
ORGANISM(S): Mus musculus (Mouse) 
2019-02-16 | PXD009981 | Pride
Mouse retina proteome Phosphoproteome Swiss-webster nd4 
TranscriptomicsSingle cell RNAseq of 12-week old AKIMBA versus WT mouse retina
Single-cell RNA sequencing was performed on retinal tissue from 12-week-old wild-type and Akimba (Ins2AkitaxVEGF+/-) mice, which are known to replicate features of clinical diabetic retinopathy. The aim of this study was to provide deeper insight into the complex network of molecular and cellular ch...
ORGANISM(S): Mus musculus 
2020-05-23 | E-MTAB-9061 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of vasoregression in the retina
Vasoregression is a hallmark of vascular eye diseases but the mechanisms involved are still largely unknown. We have recently characterized a rat ciliopathy model which develops primary photoreceptor degeneration and secondary vasoregression. To improve the understanding of secondary vasoregression ...
ORGANISM(S): Rattus norvegicus 
2011-03-15 | E-GEOD-20967 | biostudies-arrayexpress
TranscriptomicsThe alarmin IL-33 amplifies an immune response in the degenerating retina
ST2 heterodimerizes with IL-1RAcp to form the receptor for IL-33, which is primarily associated with allergic inflammation by inducing Th2 responses. Recently, however, IL-33 was found to be expressed in the central nervous system and in retinal Muller cells which imply functions, as yet undescribed...
ORGANISM(S): Mus musculus 
2015-12-17 | E-GEOD-74695 | biostudies-arrayexpress
TranscriptomicsEndothelin2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis
Endothelin signaling is required for neural crest migration and homeostatic regulation of blood pressure. Here we report that constitutive over-expression of Endothelin-2 (Edn2) in the mouse retina perturbs vascular development by inhibiting endothelial cell (EC) migration across the retinal surfac...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-50059 | biostudies-arrayexpress
ProteomicsIdentification of Proteins Significantly Affected by Ocular Hypertension in the Glaucomatous Male and Female Mouse Retina by Label-Free Proteomics Khadiza Zaman,1 Autumn B. Morgan,2 Katalin Prokai-Tatrai,1 Denis M. Inman,2 Laszlo Prokai1
PURPOSE. To identify of proteins and affected by increase of intraocular pressure in the magnetic microbead model of glaucoma in the retinae of mice considering sex as biological variable. METHODS. A sustained increase of intraocular pressure was achieved through injections of paramagnetic polystyr...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD073136 | Pride
Label-free proteomics Glaucoma Sex as biological variable Pathway analysis Mouse Bioinformatics Retina Magnetic microbead model Protein interaction networks 
ProteomicsLow-dose anti-HIV drug efavirenz mitigates retinal vascular lesions in a mouse model of Alzheimer’s disease
A small dose of the anti-HIV drug efavirenz (EFV) was previously discovered to activate CYP46A1, a cholesterol-eliminating enzyme in the brain, and mitigate some of the manifestation of Alzheimer’s disease in 5XFAD mice(a mouse model foe Alzheimers disease. Herein, we investigated the retina of thes...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-27 | PXD033037 | Pride
Mus musculus retina 
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