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MetabolomicsDe Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma

Pleural mesothelioma (PM) is one of the deadliest cancers, with limited therapeutic options due to its therapeutically intractable genome, which is characterized by the functional inactivation of tumor suppressor genes (TSGs) and high tumor heterogeneity, including diverse metabolic adaptations. ...

2025-07-07 | MTBLS12461 | MetaboLights
ProteomicsMalignant pleural mesothelioma targeted proteomics signature from blood
Targeted proteomics based blood biomarkers for malignant pleural mesothelioma cancer
ORGANISM(S): Homo Sapiens 
2020-08-03 | PXD018457 | panorama
TranscriptomicsChromosomal aberration of asbestos-induced malignant mesothelioma in rats
Exposure to asbestos is a risk for malignant mesothelioma in humans. We carried out array comparative genomic hybridization (CGH) analysis in a rat model by repeated intraperitoneal injections of three types of asbestos including chrysotile, crocidolite and amosite. We found a common chromosomal del...
ORGANISM(S): Rattus norvegicus 
2012-08-13 | E-GEOD-36577 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of Malignant Peritoneal Mesothelioma Patient Tumor Samples
Gene expression profiles were generated from 41 consecutive surgically resected fresh frozen malignant peritoneal mesothelioma patient tumor samples to identify molecular prognostic factors. Patient tumor samples hybridized against the common reference (complementary DNA generated from human univers...
ORGANISM(S): Homo sapiens 
2010-09-27 | E-GEOD-15627 | biostudies-arrayexpress
TranscriptomicsGene expression changes between primary mesothelioma tumour cells and commercially available cell lines, compared to normal primary mesothelial cells
Malignant mesothelioma (MM) is an aggressive, fatal tumour strongly associated with asbestos exposure. There is an urgent need to improve MM patient outcomes and this requires functionally validated pre-clinical models. Mesothelioma-derived cell lines provide an essential and robust tool widely used...
ORGANISM(S): Homo sapiens 
2018-02-01 | E-MTAB-6351 | biostudies-arrayexpress
TranscriptomicsExpression data generated by syndecan-1 silencing in malignant mesothelioma STAV-AB cell line
The transcriptomic responses of syndecan-1 silencing in a human mesothelioma cell line was followed with microarray analysis. To project the transcriptome analysis on the full-dimensional picture of cellular regulation, we applied a novel method of network enrichment analysis which elucidated signal...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-37843 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mesothelioma pre- and post-resistance biopsies in order to determine a resistance signature to pemetrexed/carboplatin treatment
Pemetrexed, a multi-folate inhibitor combined with a platinum compound is the first-line treatment of malignant mesothelioma, but median survival is still one year. Innate and acquired resistance to pemetrexed is common, but its biological basis is obscure. Here we report for the first time a genome...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-MTAB-1109 | biostudies-arrayexpress
TranscriptomicsHuman Mesothelioma MicroRNA Study Part 1
MicroRNA expression profiles of malignant pleural mesothelioma (MPM) specimens were analyzed to identify novel microRNA that are potentially involved in the oncogenic transformation of human pleural cells. In addition to several novel MPM-associated microRNAs, we observed that the expression level ...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-40345 | biostudies-arrayexpress
TranscriptomicsExpression data from mesothelial (LP9) and mesothelioma cells (HMESO) inhibited for extracellular-regulated kinase (ERK) 1, 2, or 5
Extracellular-regulated kinases (ERK1/2 and 5) are known to play important roles in growth and drug resistance of various cancers. Here we show roles of inhibition of ERK1, ERK2, or ERK5 on gene expression profiles of epithelioid malignant mesothelioma (MM) cells (HMESO). Untransfected human mesothe...
ORGANISM(S): Homo sapiens 
2010-05-08 | E-GEOD-21750 | biostudies-arrayexpress
TranscriptomicsLung adenocarcinoma and mesothelioma DNA methylation
Pathologic differentiation of tissue of origin in tumors found in the lung can be challenging, with differentiation of mesothelioma and lung adenocarcinoma emblematic of this problem. Indeed, proper classification is essential for determination of treatment regimen for these diseases, making accurat...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-16559 | biostudies-arrayexpress
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