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ProteomicsIQCN disruption causes fertilization failure and male infertility due to manchette assembly defect
Total fertilization failure (TFF) is an important cause of infertility; however, the genetic basis of TFF caused by male factors remain to be clarified. In this study, whole-exome sequencing was firstly used to screen for genetic causes of TFF after intracytoplasmic sperm injection (ICSI), and homoz...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-22 | PXD036197 | Pride
Iqcn  manchette  fertilization failure 
ProteomicsHipk4 is a manchette-associated protein essential for spermiogenesis
Nonobstructive azoospermia (NOA) is one of the most severe forms of male infertility, characterized by the absence of spermatozoa in the ejaculate. The etiology and genetic mechanism(s) of this disease remain largely unclear. Using Sanger sequence, we identified 12 heterozygous missense mutations an...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-02 | PXD019303 | Pride
Hipk4 Spermiogenesis Mouse 
UnknownCharacterisation of the manchette architecture and its role as transport scaffold using cryo-electron tomography.
Not available
S-EPMC12326331 | biostudies-literature
UnknownA MEIG1/PACRG complex in the manchette is essential for building the sperm flagella.
Not available
S-EPMC4352978 | biostudies-literature
UnknownCAMSAP1 role in orchestrating structure and dynamics of manchette microtubule minus-ends impacts male fertility during spermiogenesis.
Not available
S-EPMC10636317 | biostudies-literature
GenomicsLoss of Profilin3 impairs spermiogenesis by affecting acrosome biogenesis, autophagy, manchette development and mitochondrial organization
Loss of Profilin3 impairs spermiogenesis by affecting acrosome biogenesis, autophagy, manchette development and mitochondrial organization
PRJNA718299 | ENA
UnknownPFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis.
Not available
S-EPMC9481974 | biostudies-literature
ProteomicsProteomics of isolated rat manchettes
The manchette is a transient microtubular structure that plays a vital role in nuclear shaping during spermiogenesis. It comprises thousands of microtubules (MTs) that build a scaffold surrounding the distal half of the nucleus. The manchette distributes proteins and vesicles during spermiogenesis i...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-18 | PXD055902 | Pride
Manchette  imt  microtubules  actin  cell polarization Proteomics Cryo-et Spermatogenesis Spermiogenesis 
UnknownManchette-acrosome disorders during spermiogenesis and low efficiency of seminiferous tubules in hypercholesterolemic rabbit model.
Not available
S-EPMC5328279 | biostudies-literature
UnknownIQCN disruption causes fertilization failure and male infertility due to manchette assembly defect.
Not available
S-EPMC9728048 | biostudies-literature
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