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ProteomicsProtein phosphorylation landscape of mouse spermatids during spermiogenesis
Tadpole-shaped sperm is formed from round spermatid by spermiogenesis, a process with dramatic morphological changes in the final stage of spermatogenesis in testis. Protein phosphorylation, as one of the most important post-translational modifications, can regulate spermiogenesis, however, there is...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-29 | PXD011890 | Pride
Mouse spermatids Spermiogenesis Phosphorylation 
ProteomicsThe deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis
Spermiogenesis defines the final phase of male germ cell differentiation. Multiple deubiquitinating enzymes have been linked to spermiogenesis, yet the impacts of deubiquitination on spermiogenesis remain poorly characterized. Here, we investigated the function of UAF1 in mouse spermiogenesis and ma...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-07 | PXD046120 | Pride
Uaf1 usp1 male infertility spermiogenesis deubiquitylation 
ProteomicsInteractors and targeted substrates of UBL7 in mouse testis and sperm
Spermiogenesis is a tightly regulated process to produce mature sperm cells. The ubiquitin-proteasome system (UPS) plays a crucial role in controlling protein half-life and is essential for spermiogenesis. In this study, we demonstrate that UBL7, a testis-enriched UBL-UBA protein, is indispensable f...
ORGANISM(S): Mus Musculus 
2025-03-04 | PXD061424 |
ProteomicsLoss of Cep70 function affects acrosome biogenesis and flagella formation during spermiogenesis
The spermatogenesis process is complex and delicate, and any error in any step may cause spermatogenesis arrested and even male infertility. Through mutation screening of patients with clinical azoospermia, we found a heterozygous site of the same mutation on CEP70. The centrosome protein 70 (Cep70)...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD023680 | Pride
Cep70  male infertility  acrosome biogenesis  flagella formation  spermiogenesis 
ProteomicsHipk4 is a manchette-associated protein essential for spermiogenesis
Nonobstructive azoospermia (NOA) is one of the most severe forms of male infertility, characterized by the absence of spermatozoa in the ejaculate. The etiology and genetic mechanism(s) of this disease remain largely unclear. Using Sanger sequence, we identified 12 heterozygous missense mutations an...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-02 | PXD019303 | Pride
Hipk4 Spermiogenesis Mouse 
GenomicsTaf7l cooperates with Trf2 to regulate spermiogenesis
Taf7l (a paralogue of Taf7) and Trf2 (a TBP-related protein) are components of the core promoter complex required for gene/tissue-specific transcription of protein-coding genes by RNA polymerase II. Previous studies reported that Taf7l knockout mice exhibit structurally abnormal sperm, reduced sperm...
ORGANISM(S): Mus musculus 
2013-09-29 | E-GEOD-50807 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse germline during spermatogenesis reveals X and Y occupy a novel compartment in the post-meiotic spermatid and adopt a non-Rabl configuration
In mammals, the X and Y chromosomes are subject to meiotic sex chromosome inactivation (MSCI) during prophase I in the male germline, but their status thereafter is currently unclear. An abundance of X-linked spermatogenesis genes has spawned the view that the X must be active [1-8]. On the other ha...
ORGANISM(S): Mus musculus 
2007-12-07 | E-GEOD-4193 | biostudies-arrayexpress
ProteomicsFBXO24 targets SLC25A26 for K6-linked polyubiquitination to maintain mitochondrial function during spermiogenesis
FBXO24 targets SLC25A26 for K6-linked polyubiquitination to maintain mitochondrial function during spermiogenesis
ORGANISM(S): Mus Musculus 
PXD063867 |
TranscriptomicsTarget RNA repertoire of mouse Mili and Miwi proteins reveals piRNA biogenesis and Miwi function in spermiogenesis [HITS-CLIP]
Germ cells employ elaborate mechanisms to maintain and protect their genetic material, and also to regulate gene expression during the complex differentiation process of gametogenesis. Piwi proteins, a subclade of the Argonaute family, are expressed mainly in the germline and bind piRNAs, a novel an...
ORGANISM(S): Mus musculus 
2012-07-19 | E-GEOD-27622 | biostudies-arrayexpress
UnknownCentriole Remodeling during Spermiogenesis in Drosophila.
Not available
S-EPMC5245371 | biostudies-literature
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