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ProteomicsAcetylation Regulates MARK2 activity
This study investigates the interactions between two enzymes involved in regulating the protein tau’s PTMs: the kinase MARK2 and the acetyltransferase CBP. Western blot analysis revealed that CBP-mediated acetylation was increased in the absence of MARK2, indicating a possible negative feedback loop...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD030937 | Pride
Mark2 Phosphorylation 
ProteomicsMARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer
Human cancer is often caused by dysfunctional developmental pathways, but such mechanisms do not always present clear opportunities for therapeutic intervention. This is exemplified by the Hippo tumor suppressor pathway, which is comprised of a kinase module that restrains the function of YAP/TAZ tr...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD044829 | Pride
Phosphorylation hippo pathway mark2/3 
ProteomicsMARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer (part2)
Human cancer is often caused by dysfunctional developmental pathways, but such mechanisms do not always present clear opportunities for therapeutic intervention. This is exemplified by the Hippo tumor suppressor pathway, which is comprised of a kinase module that restrains the function of YAP/TAZ tr...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD054192 | Pride
Phosphorylation mark2/3 lats yap 
TranscriptomicsMicrotubule Affinity-Regulating Kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.
MARK2 expression is associated with the malignant phenotype, expression of DNA repair components, NF-κB inhibition and cell cycle transcription factors in lung cancer cells We used microarrays to determine the global gene expression pattern associated with knockdown of MARK2 3 lung cancer cell lines...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-57966 | biostudies-arrayexpress
ProteomicsThe CLASP2 Protein Interaction Network in Adipocytes Links CLIP2 to AGAP3, CLASP2 to G2L1, MARK2, and SOGA1, and Identifies SOGA1 as a Microtubule-Associated Protein
CLASP2 is a microtubule-associated protein that undergoes insulin-stimulated phosphorylation and co-localization with reorganized actin and GLUT4 at the plasma membrane. To gain insight to the role of CLASP2 in this system, we developed and successfully executed a streamlined interactome approach an...
ORGANISM(S): Mus musculus (Mouse) 
2017-06-01 | PXD003674 | Pride
Ap-ms Mark2 G2l1 Interactome Saint Soga1 Clip2 Agap3 Clasp2 
UnknownMARK2 phosphorylates eIF2α in response to proteotoxic stress.
Not available
S-EPMC7951919 | biostudies-literature
UnknownMARK2 regulates C9orf72 repeat-associated non-AUG translation.
Not available
S-EPMC12646204 | biostudies-literature
UnknownMARK2 regulates chemotherapeutic responses through class IIa HDAC-YAP axis in pancreatic cancer.
Not available
S-EPMC9339507 | biostudies-literature
UnknownMARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer.
Not available
S-EPMC11609825 | biostudies-literature
UnknownMARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.
Not available
S-EPMC10147390 | biostudies-literature
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