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Most sudden cardiac deaths in young people arise from hypertrophic cardiomyopathy, a genetic disease of the heart muscle, with many causative mutations found in the molecular motor beta-cardiac myosin that drives contraction. Therapeutic intervention for hypertrophic cardiomyopathy has until recentl...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-03-26 | PXD059316 | Pride
Nemaline myopathy (NM) is a genetic muscle disorder, notably caused by mutations in the NEB gene (NEB-NM). Here we investigated the efficacy of a four-week Mavacamten (myosin ATPase inhibitor) treatment using a NEB-NM mouse model. After the four weeks, soleus muscles were extracted, muscle fibres we...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-14 | PXD051963 | Pride
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