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ProteomicsMebendazole Inhibits Histoplasma capsulatum In Vitro Growth and Decreases Mitochondrion and Cytoskeleton Protein Levels
Histoplasmosis is a frequent mycosis in people living with HIV/AIDS and other immunocompromised hosts. Histoplasmosis has high rates of mortality in these patients if treatment is unsuccessful. Itraconazole and amphotericin B are used to treat histoplasmosis; however, both antifungals have potential...
ORGANISM(S): Fungi Histoplasma capsulatum 
2023-03-22 | PXD033762 | Pride
Histoplasma capsulatum  mebendazole  drug repositioning. antifungal activity Proteomic analysis 
GenomicsTargeting the unwindosome by mebendazole is a vulnerability of chemoresistant hepatoblastoma
Targeting the unwindosome by mebendazole is a vulnerability of chemoresistant hepatoblastoma
PRJNA862538 | ENA
ClinicalMebendazole as Adjuvant Treatment for Colon Cancer
mebendazole treating colon cancer
2303689 | ecrin-mdr-crc
TranscriptomicsTargeting the unwindosome by mebendazole is a vulnerability of chemoresistant hepatoblastoma
We identified mebendazole as a drug to circumvent chemoresistance in hepatoblastoma cell lines that are resistant to cisplatin. In order to identify the mechanistic basis of mebendazole function, we performed gene expression analysis of three mebendazole-treated hepatoblastoma cell lines.
ORGANISM(S): Homo sapiens 
2022-07-28 | GSE209824 | GEO
GenomicsWhole genome CRISPR drop-out screen in THP-1 cells exposed to mebendazole
Whole genome CRISPR drop-out screen in THP-1 cells exposed to mebendazole
PRJNA1242722 | ENA
OtherWhole genome CRISPR drop-out screen in THP-1 cells exposed to mebendazole
We previously reported that mebendazole is an effective anti-AML therapeutic and acts via induction of MYB degradation. The present experiemnt was performed in order to uncover pathways of potential resistance in AML cells to mebendazole exposure. A whole genome CRISPR drop-out screen was performed ...
ORGANISM(S): Homo sapiens 
2026-04-01 | GSE293063 | GEO
TranscriptomicsExpression analysis of Mebendazole treated THP-1 cells in three paired samples
Mebendazole treatment of MLL rearanged cell line THP-1
ORGANISM(S): Homo sapiens 
2017-03-14 | GSE96544 | GEO
GenomicsHuman fecal 16s metagenome
Effect of mebendazole treatment in human fecal metagenome
PRJNA379186 | ENA
UnknownSafety of Mebendazole Use During Lactation: A Case Series Report.
Not available
S-EPMC5045833 | biostudies-literature
UnknownTargeting the Unwindosome by Mebendazole Is a Vulnerability of Chemoresistant Hepatoblastoma.
Not available
S-EPMC9454988 | biostudies-literature
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