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GenomicsAdaptive ER stress promotes mitochondrial remodelling and longevity through PERK-dependent MERCS assembly
Adaptive ER stress promotes mitochondrial remodelling and longevity through PERK-dependent MERCS assembly
PRJNA1204992 | ENA
UnknownThe Interplay of Microtubules with Mitochondria-ER Contact Sites (MERCs) in Glioblastoma.
Not available
S-EPMC9030160 | biostudies-literature
UnknownCharacterizing mitochondrial phenotypes and MERCS in aged human skeletal muscle myoblasts.
Not available
S-EPMC12923047 | biostudies-literature
TranscriptomicsAdaptive ER stress promotes mitochondrial remodelling and longevity through PERK-dependent MERCS assembly
The transfer of information and metabolites between the mitochondria and the endoplasmic reticulum (ER) is mediated by mitochondria-ER contact sites (MERCS), allowing adaptations in response to changes in cellular homeostasis. MERCS are dynamic structures essential for maintaining cell homeostasis t...
ORGANISM(S): Caenorhabditis elegans 
2026-02-03 | GSE285634 | GEO
GenomicsRHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether
CRISPRi screening identifies RHOA as a novel MERCS regulator
PRJEB101751 | ENA
UnknownModulation of Mitochondria-Endoplasmic Reticulum Contacts (MERCs) by Small Molecules as a New Strategy for Restoring Lipid Metabolism in an Amyotrophic Lateral Sclerosis Model.
Not available
S-EPMC11770630 | biostudies-literature
GenomicsREDD1 Regulates MERCS, Protein Synthesis and NMJ Stability in Fast Myofibers During Dexamethasone-Induced Muscle Wasting
REDD1 Regulates MERCS, Protein Synthesis and NMJ Stability in Fast Myofibers During Dexamethasone-Induced Muscle Wasting
PRJNA1530507 | ENA
ProteomicsGenome-Wide CRISPR/Cas9 Screen shows that inhibiting GET4 is neuroprotective and increases mitochondrial-endoplasmic reticulum contact sites
Organelles form contacts between each other allowing for transfer of molecules and signals. Mitochondria-ER Contact sites (MERCS) are lengths of the Mitochondria and ER membrane which come together but do not fuse. They have been implicated in many diseases, including neurodegenerative, metabolic, a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042710 | Pride
Mitochondrial-er contact site Neuroprotection Ip-mass spectrometry 
TranscriptomicsEffect of GRP75 deficiency on gene expression in DN3 thymocytes
Mitochondria and endoplasmic reticulum contacts (MERCs) regulate multiple cellular processes including cell survival and differentiation. Based on the observations that MERCs were specifically enriched in the CD4-CD8- double negative (DN) stage, we studied their role in early thymocyte development. ...
ORGANISM(S): Mus musculus 
2024-06-08 | GSE268197 | GEO
ProteomicsINTERACTOME ANALYSIS IDENTIFIES THE ROLE OF BZW2 IN PROMOTING ENDOPLASMIC RETICULUM-MITOCHONDRIAL CONTACT AND MITOCHONDRIAL METABOLISM
Maio et. al. presents a comprehensive and quantitative interactome of BZW2, a protein found to promote human cancers with little known about its molecular function. Many of the proteins identified were either mitochondrial or endoplasmic reticulum (ER) proteins, suggesting BZW2 may play a role in mi...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD041354 | Pride
Mercs Lipid metabolism. Mitochondrial metabolism Mam Calcium Bzw2 Interactome 
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