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MetabolomicsAlterations in the oral microbiome and metabolome of methamphetamine addicts

BACKGROUND: Drug addiction can seriously damage human physical and mental health, while detoxification is a long and difficult process. Although studies have reported changes in the oral microbiome of methamphetamine (METH) addicts, the role of the microbiome plays in this proces...

2023-07-24 | MTBLS7807 | MetaboLights
TranscriptomicsTranscription profiling by array of Drosophila fed methamphetamine
Methamphetamine can trigger dopamine releasing in human brain, now used as abuse drug. Some studies have shown that specific genes and proteins responded to, methamphetamine, but little is known about the overall omic response of organisms to this illicit substance. Here we demonstrate that Drosophi...
ORGANISM(S): Drosophila melanogaster 
2010-10-30 | E-GEOD-16198 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by high throughput sequencing of methamphetamine-sensitized and saline-control mouse nucleus accumbens
Using ssRNA-seq, we examined the alteration of transcription profiles in the nucleus accumbens of methamphetamine-sensitized mice. Methamphetamine was a commonly abused psychostimulant. Repeated exposure to methamphetamine elicited long-lasting cellular and molecular changes, including the aberrant ...
ORGANISM(S): Mus musculus 
2017-01-15 | E-MTAB-2843 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profile of methamphetamine-sensitized and saline-control mice examined by high throughput sequencing
Using microRNA-Seq, we examined the alteration of microRNA expression profiles in the nucleus accumbens of methamphetamine-sensitized and saline-control mice. Nucleus accumbens lysate from eight mice of each group were pooled as one sample. Two RNA samples from each group were prepared and were then...
ORGANISM(S): Mus musculus 
2022-07-13 | E-MTAB-2901 | biostudies-arrayexpress
TranscriptomicsStriatum from rats treated with methamphetamine
Comparison of striatum from rats treated with either saline or 40mg/kg methamphetamine Keywords: other
ORGANISM(S): Rattus norvegicus 
2004-09-30 | E-GEOD-1711 | biostudies-arrayexpress
TranscriptomicsTranscriptional effects of chronic heroin and methamphetamine treatment in the mouse striatum
To identify molecular effects of chronic drug treatment, heroin and methamphetamine treated animals were compared with saline treated animals at multiple time-points using microarray technology. Gene expression profile was assessed 14 h after the last dose of 1, 3, 6 or 12 days drug treatment and af...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-30305 | biostudies-arrayexpress
GenomicEarly Methamphetamine Abstinence: fMRI and Brain Function

This study included two groups of subjects, methamphetamine-dependent and healthy control participants, with the purpose of characterizing brain structure and cognition during the first month of abstinence from methamphetamine. Participants were able to participate in one or both phases of the st...

phs001198 | dbGaP
TranscriptomicsTranscriptional profiles of psychostimulant reinforcement in rats
Drug-induced alterations in transcriptional regulation play a central role in establishing the persistent neuroplasticities that occur during drug addiction. Additionally, changes in gene expression associated with drug administration provide valuable insight into the molecular basis of drug abuse. ...
ORGANISM(S): Rattus norvegicus 
2013-06-27 | E-GEOD-43748 | biostudies-arrayexpress
GenomicsPaternal methamphetamine exposure enhances methamphetamine susceptibility in male rat offspring
Paternal methamphetamine exposure enhances methamphetamine susceptibility in male rat offspring
PRJNA1259014 | ENA
ProteomicsProteomics analysis of dorsal striatum reveals changes in synaptosomal proteins following ethamphetamine self-administration in rats
Methamphetamine is a widely abused, highly addictive drug. Regulation of synaptic proteins within the brain’s reward pathway modulates addiction behaviours, the progression of drug addiction and long-term changes in brain structure and function that result from drug use. Therefore, using large scale...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2015-05-06 | PXD001443 | Pride
Lc-ms/ms Rat Shotgun proteomics Synaptosome 
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