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ProteomicsBalanced Input from the tRNA Prenyltransferase MiaA Controls the Stress Resistance and Virulence Potential of Extraintestinal Pathogenic Escherichia coli
In Escherichia coli, the highly conserved enzymes MiaA and MiaB mediate the sequential prenylation and methylthiolation of adenosine-37 within tRNAs that decode UNN codons. We found that MiaA, but not MiaB, is critical to the fitness and virulence of extraintestinal pathogenic E. coli (ExPEC), a maj...
ORGANISM(S): Escherichia coli 
2022-02-14 | PXD024782 | Pride
Expec Trna modification Extraintestinal pathogenic escherichia coli Frameshifting Urinary tract infection Bacterial fitness Translation Translational regulation Sepsis Stress response Uropathogenic Miab Miaa Fidelity Proteome 
OtherMiaA-mediated tRNA modifications couple tryptophan attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa
tRNA-modifying enzymes are emerging as key regulators of bacterial physiology. MiaA, a tRNA isopentenyltransferase, is well studied in model organisms, but its role in the opportunistic pathogen Pseudomonas aeruginosa remains unclear. Using LC–MS, nanopore tRNA sequencing, as well as transcriptional...
ORGANISM(S): Pseudomonas aeruginosa UCBPP-PA14 
2026-08-12 | GSE322698 | GEO
TranscriptomicsMiaA-mediated tRNA modifications couple tryptophan attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa [RNA-seq]
tRNA-modifying enzymes are emerging as key regulators of bacterial physiology. MiaA, a tRNA isopentenyltransferase, is well studied in model organisms, but its role in the opportunistic pathogen Pseudomonas aeruginosa remains unclear. Using LC–MS, nanopore tRNA sequencing, as well as transcriptional...
ORGANISM(S): Pseudomonas aeruginosa UCBPP-PA14 
2026-08-12 | GSE323095 | GEO
GenomicsMiaA-mediated tRNA modifications couple tryptophan attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa
MiaA-mediated tRNA modifications couple tryptophan attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa
PRJEB111160 | ENA
GenomicsMiaA-mediated tRNA modifications couple tryptophan attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa
MiaA-mediated tRNA modifications couple tryptophan attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa
PRJNA1431222 | ENA
GenomicsMiaA-mediated tRNA modifications couple tryptophan attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa [RNA-seq]
MiaA-mediated tRNA modifications couple tryptophan attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa [RNA-seq]
PRJNA1432055 | ENA
UnknownThe MiaA tRNA modification enzyme is necessary for robust RpoS expression in Escherichia coli.
Not available
S-EPMC3911166 | biostudies-literature
UnknownTrmL and TusA Are Necessary for rpoS and MiaA Is Required for hfq Expression in Escherichia coli.
Not available
S-EPMC5485728 | biostudies-literature
UnknownEffects of mutations in the Pseudomonas putida miaA gene: regulation of the trpE and trpGDC operons in P. putida by attenuation.
Not available
S-EPMC95228 | biostudies-literature
ProteomicsIntegrated Phenotypic and Activity-Based Profiling of Electrophilic Fragments Reveals New Targets for Antibiotics Development
The emergence of antibiotic resistance necessitates the discovery of novel bacterial targets and antimicrobial agents. Here, we present a bacterial target discovery framework that integrates phenotypic screening of cysteine-reactive fragments with competitive activity-based protein profiling to map ...
ORGANISM(S): Shigella flexneri S5644 Bacteria 
2025-05-07 | PXD058002 | Pride
Phenotypic screening  covalent inhibitor  antibiotics  activity-based protein profiling  fabh  miaa  pdxy 
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