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MetabolomicsMicrobiomics combined metabolomics reveals Akkermansia modulating chicken gut microenvironment to protect from gamma coronavirus infection

In this study, we comprehensively investigated the influence of gut microbiota on gamma coronavirus replication in chickens. Using multi-omics approaches, we systematically examined microbial, viral and metabolic differences among adult chickens, young chickens and young chickens subjected to fec...

2025-08-17 | MTBLS12310 | MetaboLights
MetabolomicsIntegrated Multi-Omics Analysis Reveals the Impact of Vaginal Microbiota on the Microenvironment During Cervical Precancerous Progression

In this study, 172 HPV-positive patients were enrolled, of which 103 were diagnosed with low-grade squamous intraepithelial lesion (LSIL) and 69 with high-grade squamous intraepithelial lesion (HSIL). Vaginal secretions from 90 (60 with HSIL and 30 with LSIL) of these patients were collected in 8...

2025-09-19 | MTBLS12636 | MetaboLights
MetabolomicsLong-term application of biogas slurry altered the microbial community structure and metabolites in rhizosphere soil of poplar plantations

We aim to investigate the changes in the structure and function of rhizosphere microorganisms when different concentrations of biogas slurry are applied to the rhizosphere of poplar trees. By measuring the variations and types of rhizosphere metabolites, we can determine the microbial changes and...

2025-02-21 | MTBLS12235 | MetaboLights
GenomicsDiabetes induced microbiome dysbiosis is associated with therapy resistance in Pancreatic Ductal Adenocarcinoma (PDAC)
Pancreatic cancer is the 3rd most prevalent cause of cancer related deaths in United states alone, with over 55000 patients being diagnosed in 2019 alone and nearly as many succumbing to it. Late detection, lack of effective therapy and poor understanding of pancreatic cancer systemically contribute...
ORGANISM(S): mouse gut metagenome 
2020-11-30 | E-MTAB-8739 | biostudies-arrayexpress
TranscriptomicsExpression data from oxaliplatin-treated tumors from mice pre-treated or not with antibiotics cocktail
The gut microbiota influences both local and systemic inflammation. Inflammation contributes to development, progression and treatment of cancer, but it remains unclear whether commensal bacteria affect inflammation in the sterile tumor microenvironment. Here we show that disruption of the microbiot...
ORGANISM(S): Mus musculus 
2013-12-03 | E-GEOD-51414 | biostudies-arrayexpress
TranscriptomicsSingle-cell gene expression analysis of neutrophils from mouse tumors with and without microbial treatment
We conducted single-cell gene expression analysis of neutrophils from mouse tumors with and without microbial treatment to investigate neutrophil response in the tumor microenvironment (TME). Briefly, tumor-infiltrating Ly6G+CD11b+ neutrophils were isolated from unmanipulated tumors (resting), tumor...
ORGANISM(S): Mus musculus 
2023-02-17 | E-MTAB-12642 | biostudies-arrayexpress
UnknownUncovering Microbial Composition of the Tissue Microenvironment in Bladder Cancer using RNA Sequencing Data.
Not available
S-EPMC10937280 | biostudies-literature
TranscriptomicsNOD2-dependent licensing of the microbiota predispose to transmissible inflammation and tumorigenesis in the colon.
Instability in the composition of gut bacterial communities, referred as dysbiosis, has been associated with important human intestinal disorders such as CrohnM-bM-^@M-^Ys disease and colorectal cancer. Here, we show that dysbiosis coupled to Nod2 or Rip2 deficiency suffices to cause an increased ri...
ORGANISM(S): Mus musculus 
2013-01-02 | E-GEOD-32421 | biostudies-arrayexpress
UnknownIntratumoral microbial abundance and load influence the immune microenvironment of oral squamous cell carcinoma.
Not available
S-EPMC12497615 | biostudies-literature
OtherMicrobial signals in primary and metastatic brain tumors
Gliomas and brain metastases (BrM) are associated with poor prognosis, necessitating a deeper understanding of brain tumor biology and the development of effective therapeutic strategies. While our group and others have demonstrated microbial presence in various tumors, recent controversies regardin...
ORGANISM(S): Homo sapiens 
2025-08-12 | GSE305267 | GEO
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