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The Epstein Barr virus (EBV) encoded latent membrane protein-1 (LMP1) is a functional homologue of the tumor necrosis factor receptor family and contributes substantially to the oncogenic potential of EBV through activation of Nuclear Factor-kappaB (NF-kappaB). MicroRNAs (miRNAs) are a class of smal...
ORGANISM(S): Homo sapiens 
Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. Here we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knockdown of m...
ORGANISM(S): Homo sapiens 
Analysis of human mesenchymal stem cells (MSC) from bone marrow and the Wharton's jelly of the umbilical cord after manupulating miR-146a-5p expression. miR-146a-5p is involved in controlling the proliferation and migration of MSCs. Results provide miR-146a-5p-regulating genes in MSCs. In this study...
ORGANISM(S): Homo sapiens 
We have found expression of miR-146a up-regulated in gastric cancer. To identify new targets of miR-146a we profiled the transcriptome after miR-146a over-expression in the human gastric cancer cell line SNU638. SNU638 cells were transfected in triplicates with 50 nM miR-146a or control (siGlo) usin...
ORGANISM(S): Homo sapiens 
A long-prevailing model has held that the “seed” region (nucleotides 2-8) of a microRNA is typically sufficient to mediate target recognition and repression. However, numerous recent studies, both within the context of defining miRNA/target pairs by direct physical association and by directly assess...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Pisum sativum (Garden pea) Olea europaea (Common olive) Mus musculus (Mouse) Helicobacter pylori J99 (Campylobacter pylori J99) Pongo pygmaeus (Bornean orangutan) Acyrthosiphon pisum (Pea aphid) Apis mellifera (Honeybee) Dictyostelium discoideum (Slime mold) Merluccius bilinearis (Silver hake) Cicer arietinum (Chickpea) (Garbanzo) Candida albicans (Yeast) Rattus rattus (Black rat) Gadus morhua (Atlantic cod) Homo sapiens (Human) Mesocricetus auratus (Golden hamster) Brassica oleracea var. botrytis (Cauliflower) Halobacterium salinarum Hepatitis C virus subtype 1a Rattus norvegicus (Rat) Bombyx mori (Silk moth) Enterococcus faecalis (Streptococcus faecalis) Pan troglodytes (Chimpanzee) Arabidopsis thaliana (Mouse-ear cress) Arachis hypogaea (Peanut) Cercopithecus aethiops (Green monkey) (Grivet) Pinus radiata (Monterey pine) Hordeum vulgare (Barley) Nicotiana tabacum (Common tobacco) Heliocidaris erythrogramma (Sea urchin) Gallus gallus (Chicken) Ictalurus punctatus (Channel catfish) Oryza sativa (Rice) Drosophila melanogaster (Fruit fly) Caenorhabditis elegans Bos taurus (Bovine) Solanum tuberosum (Potato) Ricinus communis Escherichia coli Saccharomyces cerevisiae (Baker's yeast) Macaca mulatta (Rhesus macaque) Staphylococcus aureus Brassica napus (Rape) Equus caballus (Horse) 
2019-02-09 | PXD011413 | Pride
miR-146a Pulldown-sequencing data
miR-146a regulates many lncRNAs in RAS induced senescence [Anti-146a]
Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. Here we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knockdown of m...
ORGANISM(S): Homo sapiens 
The aim of this study was to analyze expression differences between murine splenic miR-146a deficient and miR-146a sufficient T cells after allogeneic stimulation in vitro.
ORGANISM(S): Mus musculus 
miR-146a regulates many lncRNAs in RAS induced senescence [miR-CLIP]
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