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TranscriptomicsProteolytic inactivation of the autoinhibitory prodomain is essential for the pro-tumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP)
Invasive cancers employ pericellular proteolysis to breach the extracellular matrix and basement membrane barriers and invade the surrounding tissue. Pro-invasive, pro-tumorigenic MT1-MMP is the primary mediator of proteolytic events on the cancer cell surface. Cellular MT1-MMP is synthesized as a l...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28655 | biostudies-arrayexpress
Proteomicsintracellular MMP-2 proteolysis in cardiac tissue
Induced proteolysis of rat heart extracts with recombinant MMP-2 followed by subtiligase-N-terminomics
ORGANISM(S): Rattus (ncbitaxon:10114) 
2023-11-01 | MSV000093229 | MassIVE
ProteomicsComputational design of Matrix Metalloprotenaise-9 (MMP-9) resistant to auto-cleavage
Matrix metalloproteinase-9 (MMP-9) is an endopeptidase that remodels the extracellular matrix and has been implicated as a major driver in cancer metastasis. Hence, there is a high demand for MMP-9 inhibitors for therapeutic purposes. For such drug design efforts, large amounts of MMP-9 are required...
ORGANISM(S): Escherichia coli 
2023-10-24 | PXD041767 | Pride
Mmp-9 Auto-cleavage Protein engineering Auto-degradation Enzyme engineering Matrix metalloproteases 
TranscriptomicsGenome-wide analysis of MCF-7 cells expressing or not MMP-14 (MT1-MMP) growing in monolayer cell culture conditions
In order to investigate the impact of MMP-14 (MT1-MMP) on the transcriptomes of a human breast adenocarcinoma cell line, we performed a microarray analysis from RNAs isolated from MCF-7 cells expressing either an empty vector (VEC) or human MMP-14 cDNA (MT1) in monolayer growth conditions. MCF-7 cel...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-64320 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of control and MMP-14 (MT1-MMP) expressing MCF-7 cells growing in three-dimensional (3D) type I collagen gels versus monolayer cell culture conditions
In order to investigate the impact of MMP-14 (MT1-MMP) and three-dimensional (3D) culture conditions on the transcriptomes of a human breast adenocarcinoma cell line, we performed a microarray analysis from RNAs isolated from MCF-7 cells expressing either an empty vector (CTRL) or human MMP-14 cDNA ...
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-49595 | biostudies-arrayexpress
ProteomicsNaringenin targets PI3K p85alpha to suppress PI3K/AKT signaling pathway and ameliorate disordered MMP-9 secretion in cigarette smoke extract-induced alveolar macrophages in vitro
Naringenin has demonstrated potential therapeutic effects against cigarette smoke-induced lung injury; however, its underlying mechanisms of regulating matrix metalloproteinase-9 (MMP-9) in alveolar macrophages remain unclear. Methods: The regulatory mechanisms of naringenin in cigarette smoke extra...
ORGANISM(S): Mus Musculus 
PXD063137 |
TranscriptomicsTranscription profiling of mouse C57Bl6 MMP-7 and MMP-10 deficient mice Pseudomonas aeruginosa exposed airway epithelium.
Airway epithelium is the initial point of host-pathogen interaction in Pseudomonas aeruginosa infection, an important pathogen in cystic fibrosis and nosocomial pneumonia. We used global gene expression analysis to determine airway epithelial transcriptional responses dependent on matrilysin (MMP-7)...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7957 | biostudies-arrayexpress
ProteomicsInhibition of ß1 integrin induces its association with MT1-MMP and decreases MT1- MMP internalization and cellular invasiveness
Integrin signaling plays a fundamental role in the establishment of focal adhesions and the subsequent formation of invadopodia in malignant cancer cells. Invadopodia facilitate localized adhesion and degradation of the extracellular matrix (ECM), which promote tumour cell invasion and metastasis. D...
ORGANISM(S): Homo sapiens (Human) 
2022-12-22 | PXD024000 | Pride
Extracellular matrix  integrin  mt1-mmp  invadopodia 
GenomicsMMP-seq tumor samples (FASTQ) - samples
MMP-seq tumor samples (FASTQ)
EGAD00001001108 | EGA
GenomicsMMP-seq cell lines (FASTQ) - samples
MMP-seq cell lines (FASTQ)
EGAD00001001107 | EGA
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