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ProteomicsComputational design of Matrix Metalloprotenaise-9 (MMP-9) resistant to auto-cleavage
Matrix metalloproteinase-9 (MMP-9) is an endopeptidase that remodels the extracellular matrix and has been implicated as a major driver in cancer metastasis. Hence, there is a high demand for MMP-9 inhibitors for therapeutic purposes. For such drug design efforts, large amounts of MMP-9 are required...
ORGANISM(S): Escherichia coli 
2023-10-24 | PXD041767 | Pride
Mmp-9 Auto-cleavage Protein engineering Auto-degradation Enzyme engineering Matrix metalloproteases 
ProteomicsNaringenin targets PI3K p85alpha to suppress PI3K/AKT signaling pathway and ameliorate disordered MMP-9 secretion in cigarette smoke extract-induced alveolar macrophages in vitro
Naringenin has demonstrated potential therapeutic effects against cigarette smoke-induced lung injury; however, its underlying mechanisms of regulating matrix metalloproteinase-9 (MMP-9) in alveolar macrophages remain unclear. Methods: The regulatory mechanisms of naringenin in cigarette smoke extra...
ORGANISM(S): Mus Musculus 
PXD063137 |
GenomicsMMP-9 affects dural cell composition and granulocyte accumulation during neuroinflammation
MMP-9 affects dural cell composition
PRJEB101900 | ENA
GenomicsMMP-9 drives melanomagenic transcription program through histone H3 tail proteolysis
MMP-9 drives melanomagenic transcription program through histone H3 tail proteolysis
PRJNA743353 | ENA
ProteomicsMMP-9 dependent extracellular protein changes in the left ventriclar infarcts at day 7 post myocardial infarction
Glycopeptides of the LVI tissues of WT and MMP-9 null mice at day-7 post-MI.
ORGANISM(S): Mus musculus (Mouse) 
2018-03-06 | PXD001393 | Pride
Mmp-9 Lv Glycopeptides Myocardial infarction 
TranscriptomicsMMP-9 drives melanomagenic transcription program through histone H3 tail proteolysis
Melanoma is a type of skin cancer that develops in pigment-producing melanocytes and often spreads to other parts of the body. Aberrant gene expression has been considered as a crucial step for increasing the risk of melanomagenesis, but how chromatin reorganization contributes to this pathogenic pr...
ORGANISM(S): Homo sapiens 
2021-11-17 | GSE179367 | GEO
ProteomicsBergenin inhibits growth of human cervical cancer cells by decreasing Galectin-3 and MMP-9 expression
Cervical cancer is still the leading cause of cancer mortality worldwide even after introduction of vaccine against Human papillomavirus (HPV), due to low vaccine coverage, especially in the developing world. Cervical cancer is primarily treated by Chemo/Radiotherapy, depending on the disease stage,...
ORGANISM(S): Homo sapiens (Human) 
2024-03-04 | PXD043359 | Pride
Bergenin Hpv Cervical cancer Galectin 3 Matrix metallo protease 9 
GenomicsMMP-9-dependent proteolysis of the histone H3 N-terminal tail, a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis
MMP-9-dependent proteolysis of the histone H3 N-terminal tail, a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis
PRJNA1015360 | ENA
TranscriptomicsMMP-9-dependent proteolysis of the histone H3 N-terminal tail, a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis
The matrix metalloproteinase 9 (MMP-9) is a member of the MMP family and has been recently identified as a nuclear protease capable of clipping histone H3 N-terminal tails (H3NT). This MMP-9-dependent H3NT proteolysis is critical for establishing active state of gene transcription during osteoclast ...
ORGANISM(S): Homo sapiens 
2024-07-18 | GSE242924 | GEO
UnknownNovel Matrix Metalloproteinase-9 (MMP-9) Inhibitors in Cancer Treatment.
Not available
S-EPMC10418771 | biostudies-literature
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