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MMP-9 dependent extracellular protein changes in the left ventriclar infarcts at day 7 post myocardial infarction

ABSTRACT: Glycopeptides of the LVI tissues of WT and MMP-9 null mice at day-7 post-MI.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Yuan Tian

LAB HEAD: Merry Lindsey

PROVIDER: PXD001393 | Pride | 2018-03-06

REPOSITORIES: Pride

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CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal During Cardiac Remodeling.

DeLeon-Pennell Kristine Y KY Tian Yuan Y Zhang Bai B Cates Courtney A CA Iyer Rugmani Padmanabhan RP Cannon Presley P Shah Punit P Aiyetan Paul P Halade Ganesh V GV Ma Yonggang Y Flynn Elizabeth E Zhang Zhen Z Jin Yu-Fang YF Zhang Hui H Lindsey Merry L ML

Circulation. Cardiovascular genetics 20151117 1

<h4>Background</h4>After myocardial infarction, the left ventricle undergoes a wound healing response that includes the robust infiltration of neutrophils and macrophages to facilitate removal of dead myocytes as well as turnover of the extracellular matrix. Matrix metalloproteinase (MMP)-9 is a key enzyme that regulates post-myocardial infarction left ventricular remodeling.<h4>Methods and results</h4>Infarct regions from wild-type and MMP-9 null mice (n=8 per group) analyzed by glycoproteomics ...[more]

PMID: 26578544

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