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Sepsis related glycopeptides - Plasma Glycoproteomics Reveals Sepsis Outcomes Linked to Distinct Proteins in Common Pathways

ABSTRACT: The plasma of the sepsis patient survivors and non-survivors (n=10/group) were analyzed using glycoproteomics approach.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Lemierre's Syndrome

SUBMITTER: Yuan Tian

LAB HEAD: Merry L. Lindsey

PROVIDER: PXD001425 | Pride | 2018-10-19

REPOSITORIES: Pride

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			Action	DRS
	Glyco_1.msf	Msf
	Glyco_1.pep.xml	Pepxml
	Glyco_1.raw	Raw
	Glyco_10.msf	Msf
	Glyco_10.pep.xml	Pepxml

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Plasma Glycoproteomics Reveals Sepsis Outcomes Linked to Distinct Proteins in Common Pathways.

DeCoux Ashley A Tian Yuan Y DeLeon-Pennell Kristine Y KY Nguyen Nguyen T NT de Castro Brás Lisandra E LE Flynn Elizabeth R ER Cannon Presley L PL Griswold Michael E ME Jin Yu-Fang YF Puskarich Michael A MA Jones Alan E AE Lindsey Merry L ML

Critical care medicine 20151001 10

<h4>Objective</h4>Sepsis remains a predominant cause of mortality in the ICU, yet strategies to increase survival have proved largely unsuccessful. This study aimed to identify proteins linked to sepsis outcomes using a glycoproteomic approach to target extracellular proteins that trigger downstream pathways and direct patient outcomes.<h4>Design</h4>Plasma was obtained from the Lactate Assessment in the Treatment of Early Sepsis cohort. N-linked plasma glycopeptides were quantified by solid-pha ...[more]

PMID: 26086942

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