Proteomics

Dataset Information

0

Sepsis related glycopeptides - Plasma Glycoproteomics Reveals Sepsis Outcomes Linked to Distinct Proteins in Common Pathways


ABSTRACT: The plasma of the sepsis patient survivors and non-survivors (n=10/group) were analyzed using glycoproteomics approach.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Lemierre's Syndrome

SUBMITTER: Yuan Tian  

LAB HEAD: Merry L. Lindsey

PROVIDER: PXD001425 | Pride | 2018-10-19

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Glyco_1.msf Msf
Glyco_1.pep.xml Pepxml
Glyco_1.raw Raw
Glyco_10.msf Msf
Glyco_10.pep.xml Pepxml
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Publications


<h4>Objective</h4>Sepsis remains a predominant cause of mortality in the ICU, yet strategies to increase survival have proved largely unsuccessful. This study aimed to identify proteins linked to sepsis outcomes using a glycoproteomic approach to target extracellular proteins that trigger downstream pathways and direct patient outcomes.<h4>Design</h4>Plasma was obtained from the Lactate Assessment in the Treatment of Early Sepsis cohort. N-linked plasma glycopeptides were quantified by solid-pha  ...[more]

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