Sepsis related glycopeptides - Plasma Glycoproteomics Reveals Sepsis Outcomes Linked to Distinct Proteins in Common Pathways
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Plasma
DISEASE(S): Lemierre's Syndrome
SUBMITTER: 
Yuan Tian
LAB HEAD: Merry L. Lindsey
PROVIDER: PXD001425 | Pride | 2018-10-19
REPOSITORIES: Pride
Publications
Plasma Glycoproteomics Reveals Sepsis Outcomes Linked to Distinct Proteins in Common Pathways.
DeCoux Ashley A Tian Yuan Y DeLeon-Pennell Kristine Y KY Nguyen Nguyen T NT de Castro Brás Lisandra E LE Flynn Elizabeth R ER Cannon Presley L PL Griswold Michael E ME Jin Yu-Fang YF Puskarich Michael A MA Jones Alan E AE Lindsey Merry L ML
Critical care medicine 20151001 10
<h4>Objective</h4>Sepsis remains a predominant cause of mortality in the ICU, yet strategies to increase survival have proved largely unsuccessful. This study aimed to identify proteins linked to sepsis outcomes using a glycoproteomic approach to target extracellular proteins that trigger downstream pathways and direct patient outcomes.<h4>Design</h4>Plasma was obtained from the Lactate Assessment in the Treatment of Early Sepsis cohort. N-linked plasma glycopeptides were quantified by solid-pha ...[more]
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