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GenomicsMatrix-anchored Nanoparticles for MMP13 RNA Interference Block Post-Traumatic Osteoarthritis
Matrix-anchored Nanoparticles for MMP13 RNA Interference Block Post-Traumatic Osteoarthritis
PRJNA718183 | ENA
ProteomicsProteolytic information flows from human knee osteoarthritic cartilage to synovial fluid and defines the roles of key drug targets -1
Objectives: Proteolytic cartilage loss is a major mechanism of osteoarthritis (OA) pathogenesis but few joint breakdown biomarkers are currently available. We sought to determine the overlap of proteolytic peptides in OA cartilage and synovial fluid on a proteome-wide scale with the goals of increa...
ORGANISM(S): Homo sapiens (Human) 
2025-02-04 | PXD048053 | Pride
Proteolysis Synovial fluid Cartilage Protease Proteomics Osteoarthritis 
TranscriptomicsGene expression profiling of experimental granulation tissue in Mmp13-/- mice compared to wild type mice
Proteinases play a pivotal role in wound healing by degrading molecular barriers, regulating cell-matrix interactions and availability of bioactive molecules. Matrix metalloproteinase-13 (MMP-13, collagenase-3) is a wide spectrum proteinase. Its expression and function is linked to the growth and in...
ORGANISM(S): Mus musculus 
2012-08-07 | E-GEOD-38822 | biostudies-arrayexpress
GenomicsGenome wide analysis of the effect of MMP13-ablation on mouse dental pulp tissue
Genome wide analysis of the effect of MMP13-ablation on mouse dental pulp tissue
PRJNA741474 | ENA
ProteomicsVulnerability of Progeroid Smooth Muscle Cells to biomechanical forces is mediated by MMP13
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS patients, although the reason for such vulnerability remains poorly understood. In this work, we developed a chip formed from...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-24 | PXD011652 | Pride
Disease modelling Induced pluripotent stem cells Therapies Aging : progeria 
ProteomicsVulnerability of Progeroid Smooth Muscle Cells to biomechanical forces is mediated by MMP13
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS patients, although the reason for such vulnerability remains poorly understood. In this work, we developed a chip formed from...
ORGANISM(S): Homo sapiens (Human) 
2020-08-24 | PXD019316 | Pride
Disease modelling Induced pluripotent stem cells Therapies Progeria Aging 
TranscriptomicsMatrix-anchored Nanoparticles for MMP13 RNA Interference Block Post-Traumatic Osteoarthritis
Targeting MMP13 directly by RNA interference (RNAi) silenced MMP13 in a murine post-traumatic osteoarthritis (PTOA) and was found to have broad effects on overall joint health, including both the articular cartilage and surrounding hard and soft tissues. To further characterize the global impacts of...
ORGANISM(S): Mus musculus 
2021-04-17 | GSE171031 | GEO
UnknownMMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO).
Not available
S-EPMC1201660 | biostudies-literature
UnknownOsteocyte-Intrinsic MMP13 exacerbates injury-induced temporomandibular joint osteoarthritis.
Not available
S-EPMC12912257 | biostudies-literature
UnknownETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.
Not available
S-EPMC6042225 | biostudies-literature
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