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MetabolomicsUntargeted Metabolomics To Ascertain Antibiotic Modes of Action
Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially rapid and cost-effective means of identifying modes of action of drugs whose effects are mediated through changes in metabolism. Metabolomics...
2017-06-16 | MTBLS464 | MetaboLights
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087954 | MassIVE
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087949 | MassIVE
TranscriptomicsMicroarray analysis for the Mode-of-Action study of resveratrol in fission yeast
An increasing number of studies have shown that the promising compound resveratrol treats multiple diseases, such as cancer and aging; however, the resveratrol mode-of-action (MoA) remains largely unknown. Here, by virtue of multiple omics approaches, we adopted fission yeast as a model system with ...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2016-05-18 | E-MTAB-4399 | biostudies-arrayexpress
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 3
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087953 | MassIVE
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 4
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087952 | MassIVE
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 6
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-06 | MSV000087955 | MassIVE
ProteomicsPredictive Signatures of 19 Antibiotic-Induced Escherichia coli Proteomes
Identifying the mode of action (MOA) of antibacterial compounds is the fundamental basis for the development of new antibiotics, and the challenge increases with the emerging secondary and indirect effect from antibiotic stress. Although various omics-based system biology approaches are currently av...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2020-10-09 | MSV000086253 | MassIVE
ProteomicsExploring the mode of action of a novel antileishmanial compound using thermal proteome profiling and other OMICs tools
Compound 4, an antileishmanial compound identified in a GSK phenotypic-screen against Leishmania donovani (Leish-box)1 and not currently being actively researched for drug discovery, was investigated with the aim of elucidated its mode-of-action (MoA) in L. major and L. mexicana (two causative agent...
ORGANISM(S): Leishmania mexicana Leishmania major 
2025-05-10 | PXD063779 | Pride
Omics Thermal proteome profiling Leishmania Mode of action 
MetabolomicsHost-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restric...
2018-02-12 | MTBLS452 | MetaboLights
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