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MetabolomicsPromoting of microplastic intake on gastric epithelial cell carcinogenesis and its molecular mechanism.

The core objective of this study is to clarify the promoting effect of oral ingestion of microplastics on gastric epithelial cell carcinogenesis, systematically decipher the underlying molecular regulatory mechanisms, focus on investigating the key molecular targets involved in oxidative stress i...

2026-01-06 | MTBLS13588 | MetaboLights
MetabolomicsGenetic mapping and molecular mechanism behind color variation in the Asian vine snake

BACKGROUND: Reptiles exhibit a wide variety of skin colors, which serve essential roles in survival and reproduction. However, the molecular basis of these conspicuous colors remains unresolved.

RESULTS: We investigate color morph-enriched Asian vine snakes...

2023-02-23 | MTBLS6927 | MetaboLights
MetabolomicsClinacanthus nutans fractions exert anti-nasopharyngeal carcinoma effects: integrating untargeted metabolomics, network pharmacology, molecular docking and experimental validation

Background: Clinacanthus nutans (C. nutans), a Southeast Asian medicinal herb, has ethnopharmacological potential against nasopharyngeal carcinoma (NPC). This study aimed to elucidate the bioactive compounds, potential molecular targets, and regulatory pathways responsible for the anticancer acti...

2026-01-05 | MTBLS13610 | MetaboLights
MetabolomicsMetabolomics-based investigation on the molecular responses of Chaetoceros curvisetus under phosphorus limitation
Metabolomics was used in the present study to explore the molecular responses of Chaetoceros curvisetus to medium and low phosphorus stress.
2026-07-30 | MTBLS15209 | MetaboLights
MetabolomicsUntargeted Metabolomics Reveals Molecular Effects of Ketogenic Diet on Healthy and Tumor Xenograft Mouse Models
The application of ketogenic diet (KD) (high fat/low carbohydrate/adequate protein) as an auxiliary cancer therapy is a field of growing attention. KD provides sufficient energy supply for healthy cells, while possibly impairing energy production in highly glycolytic tumor cells. Moreover, KD regula...
2019-10-08 | MTBLS1066 | MetaboLights
MetabolomicsMechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomes and gut microbiome

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

2023-07-24 | MTBLS7808 | MetaboLights
MetabolomicsMolecular mechanisms of growth differences in large yellow croaker: Metabolomic and metagenomic analyses

Gut microbiota can modulate nutrient metabolism, considerably affecting host growth and development. However, mechanisms by which gut microbiota regulate large yellow croaker (LYC; Larimichthys crocea) growth remain unclear. We assessed gut contents of fast-growing male (IWHM) and female (IWHF) L...

2024-08-02 | MTBLS10000 | MetaboLights
MetabolomicsOral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

Background and Purpose: Previous studies have reported that oral low molecular weight heparin (LMWH) ameliorated colitis by undefined mechanisms in ulcerative colitis (UC) patients. Our study explored the mechanisms of LMWH on colitis from the perspective of gut microbiota and its metabolites.

2025-10-12 | MTBLS5770 | MetaboLights
MetabolomicsMolecular Basis Underlying Common Cutworm Resistance of the Primitive Soybean Landrace Peking

The common cutworm (CCW; Spodoptera litura) is one of the major insect pests of soybean in Asia and Oceania. Although quantitative trail loci related to CCW resistance have been introduced into leading soybean cultivars, these do not exhibit sufficient resistance against CCW. Thus, under...

2020-11-06 | MTBLS1960 | MetaboLights
MetabolomicsA molecular index for biological age identified from the metabolome and senescence-associated secretome in humans.
Unlike chronological age, biological age is a strong indicator of health of an individual. However, the molecular fingerprint associated with biological age is ill-defined. To define a high-resolution signature of biological age, we analyzed metabolome, circulating senescence-associated secretome (S...
2024-01-24 | MTBLS1991 | MetaboLights
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