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MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
ProteomicsSite-specific N-glycosylation Characterization of Micro Disease-related Proteins Based on EThcD-sceHCD-MS/MS
Monoclonal immunoglobulin produced by clonal plasma cells is the main cause in multiple myeloma and monoclonal gammopathy of renal significance. Because of the complicated purification method and the low stoichiometry of purified protein and glycans, site-specific N-glycosylation characterization fo...
ORGANISM(S): Homo sapiens (Human) 
2022-09-13 | PXD035757 | Pride
N-glycosylation  microscale  serum  monoclonal immunoglobulin  mass spectrometry  ethcd-scehcd 
ProteomicsGeneration and utilization of a monoclonal antibody against hepatitis B virus core protein for a comprehensive interactome analysis
Hepatitis B virus (HBV) core antigen (HBc) is a structural protein that forms the viral nucleocapsid and is involved in various steps of the viral replication cycle, but its role in the pathogenesis of HBV infection is still elusive. In this study, we generated a mouse monoclonal antibody against HB...
ORGANISM(S): Homo Sapiens (human) 
2023-02-21 | PXD036961 | JPOST Repository
TranscriptomicsTranscription profiling of human plasma cells from patients with monoclonal gammopathy of undetermined significance, multiple myeloma or plasma-cell leukaemia
This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 7 monoclonal gammopathy of undetermined significance (MGUS), 39 newly diagnosed multiple myeloma (MM) and 6 plasma-cell leukaemia (PCL) patients. PCs were purified from bone marro...
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-2113 | biostudies-arrayexpress
GenomicsRevisiting proliferative glomerulonephritis with monoclonal immunoglobulin deposits through immunoglobulin repertoire sequencing
Immunoglobulin Repertoire Analysis in PGNMID
PRJEB88838 | ENA
ProteomicsA TCR blocking HLA-A*11:01-specific human monoclonal antibody
Cross-linking mass spectrometry and Targeted cross-linking mass spectrometry for a TCR blocking human monoclonal antibody targeting HLA-A*11:01
ORGANISM(S): Homo Sapiens (human) 
2025-06-02 | PXD053836 | JPOST Repository
UnknownA novel monoclonal antibody against the constant region of goose immunoglobulin light chain.
Not available
S-EPMC3998674 | biostudies-literature
TranscriptomicsDNA methylation in normal PC, MGUS, SMM and MM
To characterize epigenomic changes during the transformation of normal plasma cells to myeloma, we used the HELP assay to analyze the methylome of CD138+ cells from 56 subjects representing premalignant (MGUS), early and advanced stages of myeloma as well as healthy controls. Plasma cells from prem...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-43860 | biostudies-arrayexpress
UnknownBoth Monoclonal and Polyclonal Immunoglobulin Contingents Mediate Complement Activation in Monoclonal Gammopathy Associated-C3 Glomerulopathy.
Not available
S-EPMC6175995 | biostudies-literature
ProteomicsDe novo sequencing of monoclonal immunoglobulin light chains associated with LCPT
This project provides high-resolution LC-MS/MS datasets dedicated to the de novo sequencing of monoclonal immunoglobulin light chains (FLCs) associated with light chain proximal tubulopathy (LCPT). LCPT is a rare renal manifestation of plasma cell dyscrasias, characterized by proximal tubule dysfunc...
ORGANISM(S): Homo Sapiens 
PXD076770 |
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