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Tuberculosis (TB) is one of major causes of death worldwide. Bacillus Calmette-Guerin (BCG) is the only licensed TB vaccine and its inability to protect against adult pulmonary TB can be due to genetic differences among strains described since the 1940s. In this work, we compared the proteomic profi...
ORGANISM(S): Mycobacterium bovis BCG str. Moreau RDJ 
2019-05-15 | PXD006141 | Pride
Emerging evidence indicates that metabolic enzymes perform moonlighting functions during tumor progression, including the modulation of chemoresistance. However, the underlying mechanisms of these functions remain elusive. In this study, utilizing a metabolic CRISPR-Cas9 knockout library screen, we ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-15 | PXD055376 | Pride
Nucleus-Translocated GCLM Promotes Chemoresistance in Colorectal Cancer through a Moonlighting Function
Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia
We comprehensively profiled intracellular and ECM proteomes of S. aureus flow biofilms and complemented these data by metabolic footprint analysis and phenotypic assays. We show that S. aureus biofilms produce high amounts of secreted, moonlighting virulence factors stabilizing the ECM. Mechanistica...
ORGANISM(S): Staphylococcus aureus subsp. aureus NCTC 8325 
2019-03-13 | PXD011157 | Pride
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