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MetabolomicsElevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism
Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and env...
2025-03-31 | MTBLS975 | MetaboLights
ProteomicsDifferential quantitative proteome analysis of cerebellar flocculus on oculomotor behavior training mouse model
Oculomotor behavior model system is commonly employed to study the neural circuits and the cellular mechanisms underlying neural integration related to motor behavior. The flocculus is a small lobe at the posterior border of the middle cerebellar and involved in motor control to aid in the oculomoto...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD008433 | Pride
Tmt labeling Flocculus Oculomotor behavior mouse model 
TranscriptomicsGlobal gene expression profile and splicing events of iPS-derived motorneurons from SMA patient, unaffected father and TGC-treated cells
Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Motoneurons derived from induced pluripotent stem cells (iPSC) obtained by reprogramming SMA patient and his healthy father fibroblasts, and gene...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27205 | biostudies-arrayexpress
TranscriptomicsIndividual bee brain behavior-age
This experiment examines gene expression profiles in individual honey bee brains (adult worker Apis mellifera). The purpose is to test whether behavioral phenotype can be predicted by expression profiles in individual brains in a naturalistic context (i.e., colonies in the field). The two behavioral...
ORGANISM(S): Apis mellifera 
2011-02-03 | E-MEXP-24 | biostudies-arrayexpress
Genomics
Motor stereotypic behavior in captive rhesus macaque
PRJNA670320 | ENA
TranscriptomicsGene Expression Analysis of native and disease-corrected motor neurons from human spinal muscular atrophy induced pluripotent stem cells free of vector and transgenic sequences
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27207 | biostudies-arrayexpress
ProteomicsHDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations
TDP-43 is the major component of pathological inclusions in most ALS patients and in up to 50% of patients with frontotemporal dementia (FTD). Heterozygous missense mutations in TARDBP, the gene encoding TDP-43, are one of the common causes of familial ALS. In this study, we investigate TDP-43 prote...
ORGANISM(S): Homo sapiens (Human) 
2021-03-15 | PXD023852 | Pride
Induced pluripotent stem cells Axonal transport Tdp-43 Als Tardpb mutation Hdac6 Interactome 
GenomicsParaoxonase 2 Deficiency in Mice Alters Motor Behavior and Causes Region-Specific Transcript Changes in the Brain
Paraoxonase 2 Deficiency in Mice Alters Motor Behavior and Causes Region-Specific Transcript Changes in the Brain
PRJNA706455 | ENA
TranscriptomicsRnf41 is associated with anxiety like behavior, major depression and beta carboline induced seizure
The molecular etiology of invididual differences in complex behavior traits and susceptibility to psychiatric illness remains incomplete. Using an unbiased genetic approach in a mouse model, Quantitative Trait Loci (QTL) influencing anxiety-like behaviors and beta-carboline-induced seizure vulnerabi...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8641 | biostudies-arrayexpress
UnknownThermoresponsive motor behavior is mediated by ring neuron circuits in the central complex of Drosophila.
Not available
S-EPMC7794218 | biostudies-literature
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