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MetabolomicsZika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA

ZIKV infection is associated with testicular damage and abnormal spermatogenesis. However, the molecular mechanisms underlying these pathogenic processes remain unclear. Here, we demonstrate that ZIKV disrupts Leydig cells' ability to produce testosterone, leading to decreased sperm counts and mo...

2025-06-29 | MTBLS12549 | MetaboLights
MetabolomicsN-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression
Various cancers such as colorectal cancer (CRC) are associated with alterations in protein glycosylation. CRC cell lines are frequently used to study these (glyco)biological changes and their mechanisms. However, differences between CRC cell lines with regard to their glycosylation have hitherto bee...
2017-02-03 | MTBLS227 | MetaboLights
TranscriptomicsRole of mRNA stability during bacterial adaptation
Bacterial adaptation involves extensive cellular reorganization. In particular, growth rate adjustments are associated with substantial modifications of gene expression and mRNA abundance. In this work we aimed to assess the role of mRNA degradation during such variations. A genome-wide transcript...
ORGANISM(S): Lactococcus lactis 
2014-06-16 | E-GEOD-43875 | biostudies-arrayexpress
ProteomicsHuman RNase 4 Improves mRNA Sequence Characterization by LC-MS/MS.
With the rapid growth of synthetic messenger RNA (mRNA)-based therapeutics and vaccines, the development of analytical tools for characterization of long, complex RNAs has become essential. Tandem liquid chromatography-mass spectrometry (LC-MS/MS) permits direct assessment of the mRNA primary sequen...
ORGANISM(S): synthetic RNA 
2022-07-26 | PXD033334 | Pride
Mrna  human rnase4 
ProteomicsProteome of the salivary gland mRNA bettween 5 instar larva and diapause larva of CBT
Proteome of the salivary gland mRNA bettween 5 instar larva and diapause larva of CBT
ORGANISM(S): Clanis Bilineata 
2024-12-16 | PXD058883 |
ModelsFirczuk2013 - Eukaryotic mRNA translation machinery
Firczuk2013 - Eukaryotic mRNA translation machinery This is a model of Saccharomyces cerevisiae mRNA translation which includes the initiation, elongation and termination phases. The model is for 20 condon mRNAs. The building of a multi-factor complex in initiati...
2024-09-02 | BIOMD0000000457 | BioModels
ProteomicsThe Parkinson's disease protein alpha-synuclein is a direct modulator of Processing-bodies and mRNA stability
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR,Carr SA, de Jager P, Myers CL, Lindquist S, Greenmyre TJ, Bartel DP, Feany MB, Sunyaev S, Chung CY and Khurana V. Alp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089026 | MassIVE
ProteomicsThe mRNA-bound proteome of Leishmania mexicana is stage-regulated with distinct transcript target pools
Leishmania species parasite infections, termed the leishmaniases, cause significant global infectious disease burden. The lifecycle of the parasite embodies three main stages that require precise coordination of gene regulation to survive drastic environmental shifts transitioning from sandfly to ma...
ORGANISM(S): Leishmania Mexicana (ncbitaxon:5665) 
2018-10-11 | MSV000083023 | MassIVE
ProteomicsIdentification of mRNA processing complexes bound to histone H2A.2 3’ untranslated region
Processing of 3’ untranslated region (3’-UTR) of precursor messenger RNAs (pre-mRNA) is a fundamental step in mRNA maturation, where the mRNA transcript is cleaved at a specific site, located downstream the open reading frame of the encoded gene. The position of the cleavage site is determined by ci...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-12-09 | PXD034984 | Pride
Pre-mrna processing Processing factors Nanolc-ms/ms Mrna maturation 
ProteomicsPytheas SARS-CoV-2 spike protein mRNA sample analysis
Mass spectrometry remains an important method for analysis of modified nucleosides ubiquitously present in cellular RNAs, in particular for ribosomal and transfer RNAs that play crucial roles in mRNA translation and decoding. Furthermore, modifications have effect on the lifetimes of nucleic acids i...
ORGANISM(S): Escherichia coli 
2022-05-04 | PXD030845 | Pride
Isotope labeling Sars-cov-2 spike protein Pytheas Mrna 
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