multi-targeted bacterial inhibition

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CHEBI ID

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Metabolite Name

(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (1)
4-Diphosphocytidyl-2-C-methylerythritol (1)
2-C-Methyl-d-erythritol-2,4-cyclopyrophosphate (1)
SM 9:1;2O/26:1 (1)
N'2-acetylpyridine-2-carbohydrazide (1)
SM 8:1;2O/28:1 (1)
SM 14:3;2O/9:0 (1)
PC 17:0_18:0 (1)
PC 19:2_20:5 (1)
PC O-33:7 (1)
PC O-41:6 (1)
LDGCC 22:5 (1)
PC O-41:4 (1)
N1-pyrazin-2-yl-4-chlorobenzamide (1)
PC O-35:3 (1)
PC O-36:7 (1)
PC 42:5_44:12 (1)
N-{6-[4-(tert-butyl)phenoxy]-3-pyridinyl}-N'-(2-thienyl)urea (1)
N-[methyl(oxo)phenyl-lambda~6~-sulfanylidene]-N'-phenylurea (1)
SM 8:1;2O/34:9 (1)
N-benzoyl-N'-(2-chlorophenyl)thiourea (1)
SM 15:3;2O/18:5 (1)
SM 8:1;2O/30:2 (1)
PC O-36:10 (1)
PC 18:0_18:0 (1)
SM 9:1;2O/26:6 (1)
SM 8:1;2O/36:5 (1)
SM 14:3;2O/7:0 (1)
PC O-41:5 (1)
Ethyl 2-[(4-methyl-2-oxo-2H-chromen-8-yl)oxy]acetate (1)

First Public Date

2026 (2)

Study type

Transcription profiling by array (5)
RNA-seq of coding RNA (2)
Unknown experiment type (1)

Release Date

2025 (4)
2026 (2)
2015 (2)
2022 (2)
2014 (1)
2012 (1)
2011 (1)
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2007 (1)
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2020 (1)

Lab affiliation

Department of Chemistry and Biochemistry, Texas Tech University (1)

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MULTI-TARGETED FLAVONOID INHIBITION OF THE PATHOGENIC BACTERIUM STAPHYLOCOCCUS AUREUS: A Proteomic Characterization

Growth inhibition of the pathogen Staphylococcus aureus with currently available antibiotics is problematic in part due to bacterial biofilm protection. While Although the recently characterized natural products, including 3´,4´,5-trihydroxy-6,7-dimethoxy-flavone [1], 3´,4´,5,6,7-pentahydroxy-flavon...

ORGANISM(S): Staphylococcus aureus

2017-05-30 | PXD006030 | Pride

Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Shotgun lipidomics assays without inhibition)

During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multi-omics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation....

2023-07-26 | MTBLS6082 | MetaboLights

Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Targeted lipidomics assay without inhibition)

2023-07-26 | MTBLS6084 | MetaboLights

Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Shotgun lipidomics assays after inhibition with FSG67 and Triacsin C)

2023-07-26 | MTBLS6083 | MetaboLights

Transcription profiling time series of S. cerevisiae wild type and upf1 mutant strains following transcription inhibition by thiolutin

Isogenic UPF1+ or upf1- yeast strains were treated with 10 ug/ml thiolutin to inhibit global transcription. Targets were obtained from 16 time points: 0, 2, 4, 6, 8, 10, 12, 15, 20, 25, 30, 35, 40, 45, 50, 60 minutes after transcription inhibition. Three biological replicates of each were generated...

ORGANISM(S): Saccharomyces cerevisiae

2007-07-12 | E-GEOD-3076 | biostudies-arrayexpress

PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer

Activating mutations of PIK3CA are the most frequent genomic alterations in estrogen receptor (ER)-positive breast tumors and selective PI3Kα inhibitors are in clinical development. The activity of these agents, however, is not homogenous and only a fraction of patients bearing PIK3CA-mutant ER-posi...

ORGANISM(S): Homo sapiens

2015-04-29 | E-GEOD-64033 | biostudies-arrayexpress

Pseudomonas fluorescens transcriptome in flowback water

The goal of the study was to examine the influence of flowback water exposure on bacterial survival and biocide tolerance. The transcriptome of P. fluorescens was analyzed using RNA-seq to determine the gene rxpression profile changes occuring upon flowback water exposure. The results indicate that ...

ORGANISM(S): Pseudomonas fluorescens

2014-12-23 | E-GEOD-55388 | biostudies-arrayexpress

Combining multi-omics analysis to identify host-targeted targets for the control of Brucella infection.

Not available

S-EPMC10686141 | biostudies-literature

The new multi-targeted agent Curaxin-137 suppresses mammary tumorigenesis in Her2/neu transgenic mice

Global gene expression profiles in liver and spleen between Curaxin-treated and control mice Gene expression profiles of samples isolated from 2 mice in each treatment group, control (plain water), and treated 0.1 and 0.2 mg/ml of Curaxin-137 from 4 to 14 weeks of age. Liver and spleen RNAs were ana...

ORGANISM(S): Mus musculus

2012-09-06 | E-GEOD-33285 | biostudies-arrayexpress

Toward biomarker-guided radiotherapy: Multi-omics analysis links ATM status to radioresistance in lung adenocarcinoma

Lung adenocarcinoma (LUAD) exhibits wide variability in radiotherapy response, yet no validated biomarkers currently guide radiation stratification. The ataxia-telangiectasia mutated (ATM) kinase plays a central role in DNA damage repair, and its loss has been associated with radiosensitivity. This ...