Sort   by:  
 Page size 
MetabolomicsBeinaglutide modulates abdominal subcutaneous adipose tissue microenvironment and lipid metabolism in diet-induced obese mice: a multi-omics analysis
Beinaglutide (BN), a recombinant human glucagon-like peptide-1 receptor agonist, exhibits beneficial effects on obesity and metabolic disorders; however, its influence on obesity-related adipose tissue alterations and associated molecular changes remains unclear. In this study, C57BL/6J mice underwe...
2026-09-23 | MTBLS15659 | MetaboLights
MetabolomicsMulti-omic profiles of human nonalcoholic fatty liver disease tissue highlight heterogenic phenotypes
Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms in, e.g. APOC3, ...
2015-12-07 | MTBLS174 | MetaboLights
MetabolomicsIntegrated Multi-Omics Mapping of Mitochondrial Dysfunction and Substrate Preference in Barth Syndrome Cardiac Tissue

Barth syndrome (BTHS) is a rare X-linked recessively inherited disorder caused by variants in the TAFAZZIN gene. The pathogenic variants lead to impaired conversion of monolysocardiolipin (MLCL) into mature phospholipid cardiolipin (CL). The accumulation of MLCL and mature CL deficiency is a diag...

2025-09-08 | MTBLS12953 | MetaboLights
GenomicsKidney tissue pipeline for multi-omics and histological analysis
Kidney tissue pipeline for multi-omics and histological analysis
PRJNA999311 | ENA
MetabolomicsSpatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies

Recent developments in spatially resolved -omics have enabled the joint study of gene expression, metabolite levels and tissue morphology, offering greater insights into biological pathways. Integrating these modalities from matched tissue sections to probe spatially-coordinated processes, howeve...

2025-12-03 | MTBLS13445 | MetaboLights
MetabolomicsMulti-omics integration analysis reveals metabolic changes during sika deer antler growth

Background: Antler is an important economic trait of sika deer (Cervus nippon), capable of rapid growth without signs of tumorigenesis. However, the molecular mechanisms underlying its unique growth pattern remain poorly understood. This study conducted a combined transc...

2026-04-01 | MTBLS12622 | MetaboLights
MetabolomicsEpimedium-Derived Extracellular Vesicles Alleviate Cisplatin-induced Acute Kidney Injury: Integrated Multi-Omics Analysis and Molecular Simulations Reveal Flavonoid Interactions with PPARα
This study explores the protective effects and potential underlying mechanisms of Epimedium-derived extracellular vesicles (EpEVs) against cisplatin-induced acute kidney injury (CIAKI) in mice. EpEVs were isolated and purified via differential centrifugation combined with sucrose and iodixanol gradi...
2026-09-02 | MTBLS15534 | MetaboLights
MetabolomicsComprehensive lipid analysis of green Arabica coffee beans by LC-HRMS/MS
Lipids play an important role in coffee bean development, coffee brew and in the effects of coffee on human health. They account for around 17% of the dry bean weight and encompass different classes and subclasses, mostly triacylglycerols (TAG) and a minor quantity of phospholipids (PL) and βN-alkan...
2021-11-19 | MTBLS1972 | MetaboLights
ModelsBordbar2011_MultiTissueType_MetabolicNetwork
This model is from the article: A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. Bordbar A, Feist AM, Usaite-Black R, Woodcock J, Palsson BO, Famili I. BMC Syst Biol. 2011 Oct 31;5(1):180. 22041191 ...
2005-01-01 | MODEL1111070003 | BioModels
MetabolomicsMultiomics analysis of neutrophils in SLE: insights from adult and pediatric disease

Neutrophils contribute to systemic lupus erythematosus (SLE) pathogenesis through ROS and NET production, and increased apoptotic debris which causes autoantibody production and immune complex formation. These processes drive inflammation and tissue damage. The aim of this study was to perform in...

2026-04-22 | MTBLS6259 | MetaboLights
Sort   by:  
 Page size