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MetabolomicsGlycaemic variability identified as a critical determinant of myocyte dysfunction and risk for myocardial injury in preclinical models of diabetes
Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population genetic data to demonstrate that current biomarkers of hyperglycaemia do not account for ris...
2026-02-06 | MTBLS11411 | MetaboLights
TranscriptomicsTranscriptional Reversion of Cardiac Myocyte Fate During Mammalian Cardiac Regeneration.
Rationale: Neonatal mice have the capacity to regenerate their hearts in response to injury, but this potential is lost after the first week of life. The transcriptional changes that underpin mammalian cardiac regeneration have not been fully characterized at the molecular level. Objective: The obje...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-64403 | biostudies-arrayexpress
GenomicsChIPseq of Myocyte Enhancer Factor 2 in neonatal rat cardiomyocytes to distinguish MEF2 binding sites
Myocyte enhancer factor 2 contributes as a transcription factor to cardiac remodeling processes. We wanted to link and compare known myocyte enhancer factor 2 targets to overall targets. Therefore, we used a model of neonatal rat cardiomyocytes and precipitated sheared chromatin samples with 5µg of ...
ORGANISM(S): Rattus norvegicus 
2017-11-21 | E-MTAB-6213 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-Seq of the murine non-myocyte cardiac cellulome
We characterized single-cell transcriptional profiles of the cardiac non-myocyte cell pool in C57BL/6J mice. The cell preparation we sequenced consisted of metabolically active, nucleated non-myocyte cells from heart ventricles of female and male mice which were depleted of endothelial cells. The go...
ORGANISM(S): Mus musculus 
2017-11-21 | E-MTAB-6173 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling in adult rat cardiomyocytes and myocyte-derived progenitor cells
TLDA miRNA profiling on purified rat cardiomyocytes (Myo) (Ctl) and myocyte-derived progenitor cells (MDCs) demonstrated significant dedifferentiation of myocytes and identity of stemness, cell cycle progression and proliferation in MDCs after continuous culture in mitogen-rich medium for about 2 we...
ORGANISM(S): Rattus norvegicus 
2010-09-22 | E-GEOD-24252 | biostudies-arrayexpress
ModelsVäremo2015 - Human myocyte metabolic model
This SBML representation of the Homo sapiens myocyte metabolic network is made available under the Creative Commons Attribution-Share Alike 3.0 Unported Licence (see www.creativecommons.org).
2016-02-10 | MODEL1503240000 | BioModels
TranscriptomicsTranscription profiling of rat neonatal ventricular myocytes plated in fibronectin reveals fibronectin induced cardiac myocyte hypertrophy
Gene expression changes in neonatal rat ventricular myocytes plated in fibronectin (2 samples) or uncoated plates (2 samples).
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1055 | biostudies-arrayexpress
GenomicsSingle cell RNA-Seq of the murine non-myocyte cardiac cellulome
Single cell RNA-Seq of the murine non-myocyte cardiac cellulome
PRJEB32371 | ENA
GenomicsDifferentially expressed fusogens specify myocyte states to drive myogenesis
Differentially expressed fusogens specify myocyte states to drive myogenesis
PRJNA1227118 | ENA
TranscriptomicsTranscription profiling of mouse sympathetic neurons cultured alone and in contact with their myocyte targets
We identified 112 known genes and 150 expressed sequence tags (ESTs) showing more than a 1.3 fold change in target-exposed neurons compared to neurons grown in the absence of target. Expression of 36 genes and 49 ESTs was upregulated, while expression of 76 genes and 101 ESTs was downregulated by t...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8393 | biostudies-arrayexpress
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